Figure 10 - H2O2 and LES.

From the following article

Signal transduction in lower esophageal sphincter circular muscle

Piero Biancani and Karen M. Harnett

GI Motility online (2006)



a: Human LES muscle mounted in muscle chambers, near conditions of optimum force development, developed steady tension after 3 to 4 hours (normal). An esophagitis specimen (esophagitis), obtained from an organ donor, had lower tone than normal strips, but tone increased after incubation in catalase.suggesting that H2O2 may be responsible for the reduced tone in esophagitis. b: Treatment of normal LES muscle with IL-1beta (200 U/mL, 2 hours) increased H2O2, and H2O2 levels were fourfold higher in LES muscle from the esophagitis specimen compared with normal muscle. Means + SE are shown for three normal LES samples. (Source: Cheng et al.,86 with permission from American Gastroenterological Association.)

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