Abstract
Aim
The aim of this study was to evaluate the cost-effectiveness of second-eye cataract surgery for older women with minimal visual dysfunction in the eye to be operated on from a Health and Personal Social Services perspective, compared to waiting list controls who had already undergone first-eye cataract surgery.
Methods
A cost-utility analysis was undertaken alongside a randomized controlled trial of second-eye cataract surgery in secondary care ophthalmology clinics. A total of 239 women over 70 years old with one unoperated cataract were randomized to cataract surgery (expedited, approximately 4 weeks) or control (routine surgery, 12 months wait). Outcomes were measured in terms of quality-adjusted life years (QALYs), with health-related quality of life estimated using the EuroQol EQ-5D.
Results
The operated group had costs which were, on average, £646 more than the control group (95% confidence interval, £16–1276, P<0.04) and had a mean QALY gain of 0.015 (95% confidence interval, −0.039 to 0.068, P=0.59) per patient over 1 year. Therefore, the incremental cost-utility ratio was £44 263 over the 1-year trial period. In an analysis modelling costs and benefits over patients’ expected lifetime, the incremental cost per QALY was £17 299, under conservative assumptions.
Conclusions
Second-eye cataract surgery is not likely to be cost-effective in the short term for those with mild visual dysfunction pre-operation. In the long term, second-eye cataract surgery appears to be cost-effective unless carer costs are included.
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Introduction
Poor vision is a risk factor for falling1 and falls can cause major clinical injuries, hospital admissions, and independence problems. We previously demonstrated that first-eye cataract surgery while just cost-ineffective in the short term did appear cost-effective when modelled over the longer term.2, 3 Bilateral cataracts are the biggest cause of poor vision in elderly patients.4 Current NHS practice is to operate on each eye separately, and increasing numbers are having the surgery performed at an earlier stage when vision may be of driving standard or better at the time of the operation leading to concerns of overutilization.5, 6, 7 The benefit of surgery for severe bilateral cataract is obvious, but it is less clear whether it is cost-effective to be operating on patients who already have good acuity following first-eye surgery.
Assessing the value for money afforded by an intervention is important, because the resources available to the NHS are fixed such that by spending money on second-eye cataract surgery we cannot use those same resources to treat something else which may afford a greater health benefit. Earlier research on the cost-effectiveness of cataract surgery is sparse (Lansingh et al8 incorporated just five cost-utility analyses of first-eye cataract surgery into a meta analysis) with most focusing on first-eye cataract surgery and relying on short-term non-randomized study designs. One other study9 has previously been published estimating the cost utility of second-eye cataract surgery in the United States. This study undertook econometric modelling using published data to determine the cost per quality-adjusted life year (QALY) for a 12 year life expectancy. They estimated the cost per QALY as $2727 (US$2001, 3% discount rate for costs and QALYs), and concluded that second-eye cataract surgery was highly cost-effective compared with interventions in other medical areas and only slightly less cost-effective than first-eye cataract surgery (US$2023).9
We previously demonstrated that second-eye cataract surgery improves visual disability and general health status (although with an uncertain effect on rate of falling).10 In this paper, we present an economic evaluation of second-eye surgery compared to first-eye surgery only (which represents what would be ‘usual care’ should second-eye cataract surgery not be performed), performing a cost-utility analysis from an NHS and personal social services perspective. Carers’ costs are presented separately.
Materials and methods
Participants and randomization
Participants were women over 70 years of age who had previously had successful first-eye cataract surgery and who had a second operable cataract. Women were excluded if they had complex cataracts, visual field defects, severe co-morbid eye disease, or memory problems that would prevent the completion of study questionnaires. Ethical committee approval was granted, and participants gave informed, written consent.
Participants were randomized to immediate second-eye cataract surgery (median time to surgery 30 days, range 8–204), or no surgery (‘waiting list’ controls, median 316 days, range 37–527). Approximately 86% of participants had baseline acuity of 6/12 or better and thus can be seen to have had good vision in the eye to be operated upon at baseline. This is an important group to study given recent concerns about overutilization of cataract surgery as a result of a reduction in the visual function threshold required for surgery to take place. Further details of the clinical trial have been published elsewhere.10
Resource use and costing
Patient diaries were used to collect individual patient level data on all contacts with health and social services, including care home admissions, use of informal care, equipment provided, and home modifications. Data were ascertained at 3 and 9 months through telephone interviews, and at 6 and 12 months through face-to-face interviews (Table 1). It was assumed that all equipment and modifications were paid for by social services with unit costs from the Personal Social Services Research Unit, where available,11 and otherwise from Internet mobility store price catalogues. Average net weekly earnings12 were applied to the time costs of informal carers, consistent with the human capital approach (Table 1). However, because the methods to cost time costs are controversial,14 carer costs were excluded from the base case as suggested by NICE15 but reported separately. All costs in this paper are presented in £2004 (inflated using the Hospital and Community Health Services inflation index,11 where necessary).
Outcomes
Patient utility was estimated using the EuroQol EQ-5D (www.euroqol.org), administered at baseline and at 6 months. The EQ-5D has five dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), each with three possible severity levels (none, some, and severe problems).16 Combining these dimensions and levels creates 243 possible health states. Each health state has an empirically measured utility score assigned,17 measured using the time-trade-off technique.18 In the base case, patient-specific utility paths were created by assuming the 6-month utility value would apply 1 month after surgery (because the benefits are likely to be felt soon after surgery) and remained constant over the remaining 11 months.
Using area under the curve analysis, taking account of baseline, we estimated the number of QALYs for the 12-month trial period for each patient. The difference in mean QALYs per patient between surgery and no surgery was calculated. The benefits were not discounted as the study was for a single year period.
Modelling longer-term cost utility
The benefits of cataract operations are lifelong.8 Using each participant's estimated life expectancy (based on age and gender) from UK government life tables, a long-term analysis was undertaken to estimate lifetime costs and benefits.19 Annual costs for the control group were assumed to remain constant in subsequent years as that observed in the trial period. Costs were significantly higher in the first quarter compared to each subsequent quarter for the intervention group (P<0.001), therefore the costs in the final three quarters of the year were rescaled to better reflect costs over a full year without a cataract operation. As with the control group, these were assumed to remain constant over the remaining lifespan.
Without cataract surgery, vision in the affected eye is likely to continue to deteriorate, and so lead to declining utility over time. However, there is little evidence about this gradient of decline in vision, and the impact of this on utility over time. Consequently, to estimate the utility gain after the last study follow-up point, in line with other economic studies,20, 21 we assumed that utility remained constant over the remaining lifetime for both groups. This is equivalent to assuming that the incremental effect (the difference in utility between the intervention and control group) is constant over remaining lifetime expectancy. Such an assumption is conservative and likely to underestimate the true gain from second-eye cataract surgery. In this lifetime analysis, both costs and benefits were discounted using a rate of 3.5% per annum in the base-case analysis.15, 22
Statistical analysis
Ten patients (4.2%) did not complete the 6-month EQ-5D questionnaire and were excluded. Patients with missing resource use data at one or more time points (around 5% of the sample due to death between data collection points or early withdrawal) were imputed using the last observed value carried forward approach and apportioned for the appropriate period. Ten participants (three who declined early surgery and seven who had early non-trial surgery) were analysed using intention to treat.
The mean difference in cost and QALYs between groups was used to generate an incremental cost-effectiveness ratio (ICER). Non-parametric bootstrap analysis was undertaken to produce cost-effectiveness acceptability curves (CEACs), where a CEAC shows the probability of an intervention being cost-effective compared to the control group for different levels of willingness to pay (WTP) per QALY.23 However, assuming one seeks to maximize health subject to a budget constraint, then the decision with regard to cost-effectiveness should be made upon the basis of the ICER, where the CEAC represents the uncertainty associated with this decision.23
Sensitivity analysis
Sensitivity analyses were performed to test the robustness of both the short- and the long-term results. We undertook threshold analysis to find the price of cataract surgery (the single largest unit cost) that would make it cost-effective. The time course of the gain in health-related quality of life was assumed to occur at 1 month after surgery in the base case. We tested this assumption by changing the time course of gain in health-related quality of life to immediately after the operation and gradually over 6 months. Finally, in the longer-term modelling we tested the impact of varying the discount rate from the 3.5% assumed in the base case to 0 and 5%, as recommended.24
We certify that all applicable institutional and governmental regulations concerning the ethical use of human volunteers were followed during this research.
Results
Data from 229 participants (116 intervention and 113 control) were included in the economic analysis. At baseline the groups were well matched.10
Resource use and costs
There were no statistically significant differences in resource use between groups at baseline. Post-intervention overall service use was higher in the operated group in the year after randomization, particularly in the first 3 months after surgery (2.8 times higher, P<0.001). Costs over months 4–12 were not statistically significantly different between groups. Seven control group patients had surgery early; the costs of this surgery were included in the analysis such that the mean resource use and cost reported, for that category, in Table 2 is not zero.
The greatest resource use and cost was for the cataract operation and hospital outpatient visits (non-cataract related) (see Table 2). The mean total cost per patient (excluding carer time costs) in the operated group was £2139 (SD 1608) compared to £1492 (SD 282) in the control group (difference £646, 95% confidence interval, £16–1276, P=0.04). Total secondary care costs (£1590 vs 632, P<0.001) and total primary health care costs (£138 vs 110, P=0.04) were also higher in the operated group. There was no statistically significant difference for personal social service costs (£411 vs 750, P=0.190) or carer time costs (£575 vs 364, P=0.14).
Cost-utility results without carer time costs included
The mean difference in QALYs per patient in the base case was 0.015 (95% confidence interval −0.039 to 0.068, P=0.59). The ICER for surgery in the base case was £44 263. Figure 1 shows the CEAC for the first year after surgery. At a WTP of £30 000 per QALY there is a 49% chance of second-eye cataract surgery being cost-effective in this population.
Cost-utility results with carer time costs included
Surgery remained more costly than control (£2713 vs 1857), and the mean cost difference (£857; 95% confidence interval, £145–1568, P=0.019) was higher. Incremental cost-effectiveness with carer time cost incorporated was £58 667.
Modelling longer-term cost utility
Extrapolating beyond the trial period to assume a time frame for analysis over expected remaining lifetime revealed a mean total cost per patient of £12 171 (SD 16 042) operated, compared with £10 887 (SD 19 823) control, mean difference of £1284 (95% confidence interval −£3420 to £5.989, P=0.591). The mean difference in QALYs per patient was 0.074 (95% confidence interval −0.38 to 0.53, P=0.75), with a long-term ICER of £17 299 when a public sector (health and social care) perspective was taken, and this mean difference applied over the remaining life expectancy. (In fact, in the 6 months utility was measured in the trial it deteriorated in the control group from 0.72 to 0.69). The long-term ICER was £41 973 when carer costs were included and benefits assumed to occur 1 month after surgery (Table 3). Figure 2 shows the CEAC for the longer-term model without carer costs. At a WTP of £30 000 per QALY, there is a 52% chance of cataract surgery being cost-effective in this population.
Sensitivity analysis
The incremental cost-utility ratios for various assumptions and sensitivity analyses are given in Table 3. The unit cost threshold for the cataract operation itself, at which the ICER fell beneath £30 000 was £454 (68% of the actual cost) for the trial period analysis. Changing the assumptions about the time course of improvement after surgery had little effect on conclusions in the trial period or longer-term analysis. Changing the discount rate from 3.5 to 0 or 5% in the longer-term modelling is unlikely to change decisions based on the ICER (see Table 3).
Conclusion
Although second-eye cataract surgery improves visual disability and general health status,10 it does so at a cost. Combining the mean change in cost and QALYs revealed that the cost-effectiveness of second-eye cataract surgery in those with good visual acuity at baseline in the short term is in excess of the implicit £20 000–30 000 WTP threshold value used by NICE15 for UK health policy purposes. However, in the longer term (over the remaining lifetime of the woman), surgery is cost-effective at a WTP threshold of £20 000 if a health and social services perspective is taken.
Second-eye cataract surgery was less cost-effective than first-eye cataract surgery in women with good baseline visual acuity,3 as others have found.9 However, the uncertainty around our results is greater than that for first-eye cataract surgery, as shown by the CEACs in both the short and the long-term analyses. This may suggest a need for further research in this area, using a large sample of patients, to reduce the uncertainty surrounding the cost-effectiveness of second-eye cataract surgery in those with minimal visual impairment pre-surgery.
We did not find second-eye cataract surgery to be as cost-effective over the longer term as described by Busbee et al9. The difference in our results may be because we used different patient populations (it is not clear whether the different data sources used by Busbee et al9 all relate to the same population, for instance) or different methods. In contrast to most other economic evaluations of cataract surgery,8 the study reported in this paper was undertaken alongside a randomized controlled trial for a 1-year follow-up period taking an NHS and personal social services perspective in the base case and in addition looked at carer costs. This means that utility estimates were derived from the cataract patients themselves, as opposed to from general ophthalmic patients.9
The literature does, however, highlight some potential limitations of using patient-reported outcome measures (PROMs), such as the EQ-5D to elicit utility and consequently to estimate QALYs, in the area of cataract surgery and other sensory-related interventions. Issues in the use of such measures in this area include, for example, that utility may be driven by the level of vision in the good eye,25 problems of practicality where respondents with vision problems cannot self-complete the questionnaires and concerns over the impact of adaptation to disability on pre-operative measures.7, 26 Although the EQ-5D is widely used,27 and, to ensure consistency, is recommended for use in cost-effectiveness analyses by NICE,15 there is a specific concern that because each dimension only has three levels of severity it may lack precision and responsiveness, making it hard to detect small changes (this concern is not specific to just sensory disabilities).28 A recent report prepared for the Department of Health found that the EQ-5D was ‘largely unresponsive’ for cataract patients (p. 38),26 a point it argues is supported by other studies (note no papers were actually referenced to back up this statement) of interventions for vision and hearing. The report speculates that lack of responsiveness may relate to the fact that instruments such as the EQ-5D and SF-6D do not incorporate sensory functions as domains in their descriptive systems.26 It was on the basis of this report that the Department of Health for England and Wales recently decided to exclude the routine assessment of PROMs for cataract surgery from its guidance on PROMs in the NHS.7, 29
A number of empirical studies have however used utility measures such as the EQ-5D. Many of these studies have found them sensitive to differences in visual acuity25, 30, 31 or able to detect significant differences for sensory interventions, including cataracts.3, 20, 21, 32 Indeed a study of first-eye cataract surgery in women with mild visual impairment found a statistically significant improvement in health status according to the EQ-5D because it captured the indirect health benefits of having the surgery.3 That is, the study reported a reduction in the number of falls experienced among those having the surgery which in turn led to reduced disability and ill-health by reducing the number of injuries such as fractures.3 Thus, the EQ-5D did detect the knock-on consequences of improved vision on health in this particular study. Therefore, it would appear wrong to conclude that instruments such as the EQ-5D cannot measure improvements in patients’ health-related quality of life at all.7 However, given the importance such measures have in evaluating cost-effectiveness and in deciding resource allocation in the modern NHS (because they enable direct comparisons of value for money to be made across a wide range of interventions for different diseases and populations), it is important to ensure methodological work in this area continues to address the concerns.33, 34, 35, 36
Our current findings diverge from our findings for first-eye surgery in terms of the importance of certain costs. For first-eye cataract surgery, personal social service costs were significantly higher for the surgery group rather than the control group and carer costs were lower for the surgery group than the control group. For second-eye cataract surgery, the reverse was found, personal social service costs were higher for the control group whereas carer costs were higher for the surgery group. This may suggest that there is likely to be some trade-off between these two types of support. The size of the difference in non-cataract-related outpatient first and follow-up visit costs is also noticeable between groups. We have no explanation for this, given the groups were well matched at baseline.
The study included a population with good acuity at baseline (86% better than Snellen 6/12 at baseline), in one centre in the UK, so results may lack generalizability. Nonetheless this is an important population to study as they make up the majority of cases awaiting second-eye cataract surgery.
The long-term modelling used the real data we had from the 1-year trial period to extrapolate what might happen if patients were followed up over their remaining life expectancy. This analysis is by nature tentative and based upon assumptions, the main assumptions being that the control group would never undergo surgery for second-eye cataract and that the difference in quality of life, between the two groups, is constant over remaining lifespan. The former assumption estimates the cost-effectiveness of second-eye cataract surgery against never having second-eye cataract surgery rather than estimate the cost-effectiveness of the timing of the surgery. The second assumption, although somewhat unrealistic, is conservative, as vision10, 37, 38, 39 and utility are likely to deteriorate in the control group over time (the mean declined from 0.72 to 0.69 in the 6-month period used to measure utility in this study), consequently the true gain in utility and true cost-effectiveness of second-eye cataract surgery in women with minimal visual impairment in the eye to be operated are likely to have been underestimated. Neither was adjustment made for the effect of increasing age on utility, because both groups would have been aging at the same rate. Given the lack of evidence about the rate of decline in vision and utility over the longer term from second-eye cataract problems for our particular sample, the longer-term model had to make some assumption about these. Rather than choosing an arbitrary rate of decline in vision and utility, which could lead to accusations of overly favouring the cost-effectiveness of second-eye surgery, we chose to take the conservative approach of assuming constant difference in utility between the two groups. In the event, we found it to be cost-effective in the long term from a public sector perspective even with such a conservative assumption. It was important to undertake this analysis, despite its limitations, because it is unrealistic to believe that cataract surgery is undertaken for 1-year gains in QALYs. In reality the benefits of cataract surgery are lifelong. However, clearly further empirical research on the long-term cost-effectiveness of second-eye cataract surgery is necessary.
The results suggest that second-eye cataract surgery is unlikely to be cost-effective (for those with minimal visual impairment pre-surgery) in the short term or in the long term if career costs are also included. The CEACs for both the short and the long term in the base case show a lot of uncertainty exists around this conclusion and are indicative of the need for more research.
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Acknowledgements
We acknowledge the funding provided by the former Trent Regional NHS Research and Development scheme and the PPP Foundation (now the Health Foundation) that made the study possible. The funders had no role in the conduct, analysis or reporting of the study.
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Sach, T., Foss, A., Gregson, R. et al. Second-eye cataract surgery in elderly women: a cost-utility analysis conducted alongside a randomized controlled trial. Eye 24, 276–283 (2010). https://doi.org/10.1038/eye.2009.112
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DOI: https://doi.org/10.1038/eye.2009.112
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