Clinical Study

Eye (2004) 18, 619–623. doi:10.1038/sj.eye.6700720

Calculated tumour volume as a prognostic parameter for survival in choroidal melanomas

E Richtig1, G Langmann2, K Müllner2, G Richtig3 and J Smolle1

  1. 1Department of Dermatology, University Hospital of Graz, Auenbruggerplatz Graz, Austria
  2. 2Department of Ophthalmology, University Hospital of Graz, Auenbruggerplatz Graz, Austria
  3. 3Department of Technical Support, Government of Styria, Landhausgasse, Graz Austria

Correspondence: E Richtig MD, Department of Dermatology, University of Graz, Auenbruggerplatz 8 Graz 8036, Austria. Tel: +43 316 385 2371; Fax: +43 316 385 2466; E-mail: erika.richtig@uni-graz.at

Received 22 April 2003; Accepted 24 July 2003.

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Abstract

Purpose Tumour diameter, tumour height, and tumour volume are considered important prognostic indicators of survival in choroidal melanomas. In this study, we investigated the prognostic impact on survival of the easily calculated volume estimate based on the assumption of a half-rotation ellipsoid.

Methods The largest tumour diameter and tumour height were measured by ultrasound A- and B-scan in 93 patients with choroidal melanoma. Tumour volume was calculated by the half volume of a rotation ellipsoid formula, rotated around the y-axis, and compared to tumour diameter and tumour height. All parameters were correlated to the clinical outcome of the patients.

Results At the time of diagnosis, the mean diameter was 10.4 mm (range 4.1–18.9 mm), and the mean height was 5.7 mm (range 1.74–14.9 mm). The range of the calculated tumour volume was between 11 and 628 mm3 (mean volume 190 mm3). Among all patients, distant metastases occurred in 10 patients (10.8%). In a univariate approach using Mantel–Haenszel log-rank test, the calculated tumour volume at the time of diagnosis was the best prognostic indicator of survival followed by tumour diameter and tumour height (P=0.028). When tumour volume, horizontal and vertical tumour diameter, age, sex, and primary tumour therapy were considered in a multivariate approach using Cox proportional Hazard model, only tumour volume turned out as a significant prognostic parameter (P=0.001).

Conclusions Calculated tumour volume is a better prognostic indicator of survival of patients with choroidal melanomas than the largest tumour diameter and tumour height, and might be established in daily routine.

Keywords:

choroidal melanoma, prognostic parameters, tumour diameter, tumour height, tumour volume, rotation ellipsoid

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