Abstract
Background/Objectives:
Sucrose-sweetened soft drinks (SSSDs) are associated with the development of metabolic disorders. Fructose is a major component of SSSDs and is demonstrated to induce uric acid (UA) production and stimulate fat accumulation independent of excess caloric intake. UA induce insulin resistance and low-grade inflammation, suggesting that UA may have a causal role in the development of metabolic complications. The objective of this study is to investigate the long-term effects of consuming SSSDs on circulating levels of UA in overweight and obese subjects.
Subjects/Methods:
Using a previously published study, circulating UA levels were assessed at baseline and after 6 months using chromogenic enzymatic absorptiometry. The study included 47 overweight and obese subjects without diabetes, randomised to consume 1 l daily of either SSSD (regular cola), isocaloric semi-skimmed milk, diet cola or water for 6 months.
Results:
Circulating UA levels increased ~15% (P=0.02) after the 6-month intervention in the SSSD group with no change in the other groups. In the SSSD group, circulating UA levels increased significantly after the intervention in both absolute (P=0.005) and relative values (P=0.004). The change in UA after the intervention correlated with changes in liver fat (P=0.005), triglycerides (P=0.02) and insulin (P=0.002).
Conclusions:
In this secondary analysis daily intake of 1 l SSSD for 6 months was found to increase circulating UA levels compared with isocaloric milk, diet cola and water. Thus, a high daily intake of SSSDs in overweight and obese subjects without overt diabetes may increase the risk of developing metabolic complications through the elevation of UA. This trial is registered at ClinicalTrials.gov as NCT00777647.
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References
Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009; 119: 1322–1334.
Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K . Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am J Physiol Endocrinol Metab 2010; 299: E685–E694.
Abdelmalek MF, Lazo M, Horska A, Bonekamp S, Lipkin EW, Balasubramanyam A et al. Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology 2012; 56: 952–960.
Sanchez-Lozada LG, Tapia E, Jimenez A, Bautista P, Cristobal M, Nepomuceno T et al. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol 2007; 292: F423–F429.
Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006; 290: F625–F631.
Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC et al. Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks. J Clin Endocrinol Metab 2011; 96: E2034–E2038.
Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC et al. Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans. Nutr Metab (Lond) 2012; 9: 68.
Sluijs I, Beulens WJ, van der A DL, Spijkerman AMW, Schulze MB, van der Schouw YT . Plasma uric acid is associated with increased risk of type 2 diabetes independent of diet and metabolic risk factors. J Nutr 2013; 143: 80–85.
Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 2013; 62: 3307–3315.
Maersk M, Belza A, Stødkilde-Jørgensen H, Ringgaard S, Chabanova E, Thomsen H et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr 2012; 95: 283–289.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419.
Sievenpiper JL, de Souza RJ, Cozma AI, Chiavaroli L, Ha V, Mirrahimi A . Fructose vs glucose and metabolism: do the metabolic differences matter? Curr Opin Lipidol 2014; 25: 8–19.
Wang DD, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Cozma AI et al. The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 2012; 142: 916–923.
Mayes PA . Intermediary metabolism of fructose. Am J Clin Nutr 1993; 58 (suppl), 754S–765SS.
The InterAct consortium. Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct. Diabetologia 2013; 56: 1520–1530.
Xu Y, Zhu J, Gao L, Liu Y, Shen J, Shen C et al. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PLoS One 2013; 8: e78206.
Jia L, Xing J, Ding Y, Shen Y, Shi X, Ren W et al. Hyperuricemia causes pancreatic beta-cell death and dysfunction through NF-kappaB signaling pathway. PLoS One 2013; 10: e78284.
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005; 11: 191–198.
Herder C, Haastert B, Müller-Scholze S, Koenig W, Thorand B, Holle R et al. Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the cooperative health research in the region of Augsburg survey S4 (KORA S4). Diabetes 2005; 54: S11–S17.
Baldwin W, McRay S, Marek G, Wymer D, Pannu V, Baylis C, Johnson RJ et al. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes 2011; 60: 1258–1269.
Acknowledgements
We thank Lenette Pedersen and Pia Hornbek for skilful technical assistance. The study was financially supported by grants from The Danish Council for Strategic Research, The Food Study Group/ Danish Ministry of Food, Agriculture and Fisheries, Novo Nordic Foundation, and Clinical Institute at Aarhus University, Denmark; the semi-skimmed milk was donated by the Danish Dairy Company, Arla Foods, but without having any influence on the design, interpretation or conclusions of the study.
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Bruun, J., Maersk, M., Belza, A. et al. Consumption of sucrose-sweetened soft drinks increases plasma levels of uric acid in overweight and obese subjects: a 6-month randomised controlled trial. Eur J Clin Nutr 69, 949–953 (2015). https://doi.org/10.1038/ejcn.2015.95
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DOI: https://doi.org/10.1038/ejcn.2015.95
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