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  • Original Article
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Carbohydrates, glycemic index and diabetes mellitus

The influence of body mass index on the accumulation of advanced glycation end products in hemodialysis patients

European Journal of Clinical Nutrition volume 69, pages 309–313 (2015)Cite this article

Subjects

A Corrigendum to this article was published on 04 March 2015

This article has been updated

Abstract

Background/Objectives:

The level of skin autofluorescence (AF) at a given moment is an independent predictor of mortality in hemodialysis (HD) patients. Skin AF is a measure of the accumulation of advanced glycation end products (AGEs). The aim of the study was to estimate the influence of nutrition on the 1-year increase of skin AF (ΔAF) in HD patients.

Subjects/Methods:

A total of 156 HD patients were enrolled in this study. Skin AF, body mass index (BMI), superoxide dismutase, myeloperoxidase, C-reactive protein, inter-cellular adhesion molecule-1, von Willebrand factor and heart-type fatty acid-binding protein were measured four times at intervals of approximately half a year. Data from the monthly routine blood analysis were also used. Daily calorie, protein and AGE intakes were assessed from food recordings over a period of 1 week.

Results:

A J-shaped relation was found between baseline BMI and ΔAF (P=0.01). The lowest point of the J-shaped curve is found for BMI=24.3 kg/m2. In the univariate analysis of the contributors to the 1-year ΔAF, we found that beside BMI=24.3 kg/m2, AGE and calorie intakes, as well as myeloperoxidase and HD vintage, had a P <0.10. The sole independent predictor of the 1-year ΔAF was BMI=24.3 kg/m2 (P=0.01).

Conclusions:

It appears that calorie, protein and AGE intakes hardly influence the 1-year ΔAF in HD patients. BMI of HD patients of around 24 kg/m2 resulted in a lower 1-year ΔAF.

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Change history

  • 04 March 2015

    This article has been corrected since advance online publication and a corrigendum is also printed in this issue

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Acknowledgements

We thank T Gruev for his assistance in the lab analysis. This work received financial support from Fresenius Medical Care Nephrocore Exchange Program.

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Authors and Affiliations

  1. Department of Nephrology, Clinical Centre, Skopje, Macedonia

    S Arsov, L Trajceska, P Dzekova & A Sikole

  2. Department of Cardiopulmonary Surgery, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands,

    W van Oeveren

  3. Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands,

    A J Smit

  4. Department of Nephrology, University Hospital, Umeå, Sweden

    B Stegmayr

  5. Department of Surgery, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands,

    G Rakhorst

  6. Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands,

    R Graaff

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Correspondence to A J Smit.

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Competing interests

Reindert Graaff and Andries J Smit are cofounders and stockholders of DiagnOptics Technologies, the manufacturer of the AGE Reader. The remaining authors declare no conflict of interest.

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Arsov, S., Trajceska, L., van Oeveren, W. et al. The influence of body mass index on the accumulation of advanced glycation end products in hemodialysis patients. Eur J Clin Nutr 69, 309–313 (2015). https://doi.org/10.1038/ejcn.2014.261

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