Original Article
European Journal of Clinical Nutrition (2009) 63, 1200–1205; doi:10.1038/ejcn.2009.51; published online 24 June 2009
Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects
Contributors: SB contributed to the experimental design, performed the FMD measurements, interpreted data, drafted the paper and performed the statistical analysis. SV contributed to the experimental design, data interpretation and the writing of the paper. JAB contributed to the interpretation of the data, critical revision of the paper and final approval of the submitted paper. MRT, SB, AM, RR and GP recruited participants and performed data collection and analysis. GC contributed to the experimental design, data interpretation, writing of the paper and trial coordination and had overall responsibility for the study.
S Buscemi1, S Verga1, J A Batsis2, M R Tranchina1, S Belmonte1, A Mattina1, A Re1, R Rizzo1 and G Cerasola1
- 1Faculty of Medicine, Department of Internal Medicine, Cardiovascular and Kidney Diseases, University of Palermo, Palermo, Italy
- 2Section of General Internal Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, US
Correspondence: Professor S Buscemi, U.O. di Medicina Interna, Nefrologia ed Ipertensione, Policlinico 'P. Giaccone', Via del Vespro, 129, I-90127, Palermo, Italy. E-mail: silbus@tin.it
Received 3 March 2009; Revised 27 April 2009; Accepted 16 May 2009; Published online 24 June 2009.
Abstract
Background/Objectives:
Coffee is known to contain antioxidant substances whose effects may be blunted because of caffeine that may unfavorably affect the cardiovascular system. This study was designed to investigate the acute dose-dependent effects of decaffeinated coffee (DC) on endothelial function measured by the brachial artery flow-mediated dilation (FMD).
Subjects/Methods:
A total of 15 (8 men and 7 women) healthy nonobese subjects underwent a single-blind, crossover study. Subjects ingested one and two cups of decaffeinated Italian espresso coffee in random order at 5- to 7-day intervals.
Results:
In the hour following the ingestion of two cups of DC, FMD increased (mean
s.e.m.): 0 min, 7.40.7%; 30 min, 8.00.6%; 60 min, 10.80.8%; P<0.001) as compared to consumption of one cup of DC (0 min, 6.90.7%; 30 min, 8.41.2%; 60 min, 8.51.1%; 3 
2 repeated-measures analysis of variance: P=0.037 for time treatment effect). Blood pressure did not differ between groups, and basal heart rate was lower in the two-cup group at baseline and 60 min.
Conclusions:
The present study demonstrated a significant acute favorable dose-dependent effect of decaffeinated espresso coffee on endothelial function. Further studies are needed to investigate the effects of chronic use of DC especially with respect to caffeinated coffee and in subjects with cardiovascular diseases.
Keywords:
decaffeinated coffee, endothelial function, FMD
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
REVIEWS
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures
American Journal of Hypertension Review
RESEARCH
Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects
Clinical Pharmacology and Therapeutics Original Article
Acute effects of renin-angiotensin system blockade on arterial function in hypertensive patients
Journal of Human Hypertension Original Article
Changes in rate and pattern of caffeine metabolism after cigarette abstinence
Clinical Pharmacology and Therapeutics Original Article
Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure
Hypertension Research Original Article
