Original Article

European Journal of Clinical Nutrition (2008) 62, 617–624; doi:10.1038/sj.ejcn.1602756; published online 18 April 2007

Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans

R P Mensink1

1Department of Human Biology, Maastricht University, Maastricht, The Netherlands

Correspondence: Professor RP Mensink, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. E-mail: R.Mensink@hb.unimaas.nl

Received 12 October 2006; Revised 19 February 2007; Accepted 2 March 2007; Published online 18 April 2007.

Top

Abstract

Background:

 

Many studies have shown that trans fatty acids have unfavorable effects on the serum lipoprotein profile. In general, however, fats were compared with different functional characteristics, which lower the practical applications of the results.

Objective:

 

The major aim of this study was to compare the effects of a high-palmitic acid, trans-free semiliquid fat with those of a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile of healthy subjects.

Subjects and design:

 

Forty-four subjects (33 women and 11 men) consumed, in random order, two experimental diets, each for 3 weeks. Diets provided 40energy percent (En%) from fat, while 15En% was supplied by the experimental fats. At the end of each intervention period, concentrations of serum lipoproteins, C-reactive protein, glucose and insulin were measured.

Results:

 

When subjects consumed the high-oleic acid, low-trans semiliquid fat, intakes of stearic acid (+1.3En%), oleic acid (+2.9En%), α-linolenic acid (+0.1En%) and trans fatty acids (+0.6En%) were higher and that of palmitic acid (−4.2En%) lower. Serum concentration of low-density lipoprotein cholesterol decreased by 0.34±0.39mmol/l (mean±s.d.; 95% confidence interval (CI), −0.46 to −0.23mmol/l; P<0.001) and high-density lipoprotein (HDL) cholesterol by −0.06±0.17mmol/l (95% CI, −0.11 to −0.01mmol/l; P=0.021). Also, the total to HDL cholesterol ratio was lower (−0.15±0.34; 95% CI, −0.25 to −0.05; P=0.006). Other parameters did not change.

Conclusions:

 

A high-oleic acid, low-trans semiliquid fat has a more favorable effect on the serum lipoprotein profile than a trans-free semiliquid fat with comparable functional characteristics, but high in palmitic acid.

Keywords:

palmitic acid, trans fatty acids, semiliquid fats, serum lipids, C-reactive protein, humans

Extra navigation

.

natureevents

ADVERTISEMENT