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Transcriptional regulation of granulocyte and monocyte development

Oncogene volume 21, pages 3377–3390 (2002)Cite this article

Abstract

Granulocytes and monocytes develop from a common myeloid progenitor. Early granulopoiesis requires the C/EBPα, PU.1, RAR, CBF, and c-Myb transcription factors, and terminal neutrophil differentiation is dependent upon C/EBPε, PU.1, Sp1, CDP, and HoxA10. Monopoiesis can be induced by Maf-B, c-Jun, or Egr-1 and is dependent upon PU.1, Sp1, and ICSBP. Signals eminating from cytokine receptors modulate factor activities but do not determine cell fates. Orchestration of the myeloid developmental program is achieved via cooperative gene regulation, via synergistic and inhibitory protein–protein interactions, via promoter auto-regulation and cross-regulation, via regulation of factor levels, and via induction of cell cycle arrest: For example, c-Myb and C/EBPα cooperate to activate the mim-1 and NE promoters, PU.1, C/EBPα, and CBF, regulate the NE, MPO, and M-CSF Receptor genes. PU.1:GATA-1 interaction and C/EBP suppression of FOG transcription inhibits erythroid and megakaryocyte gene expression. c-Jun:PU.1, ICSBP:PU.1, and perhaps Maf:Jun complexes induce monocytic genes. PU.1 and C/EBPα activate their own promoters, C/EBPα rapidly induces PU.1 and C/EBPε RNA expression, and RARα activates the C/EBPε promoter. Higher levels of PU.1 are required for monopoiesis than for B-lymphopoiesis, and higher C/EBP levels may favor granulopoiesis over monopoiesis. CBF and c-Myb stimulate proliferation whereas C/EBPα induces a G1/S arrest; cell cycle arrest is required for terminal myelopoiesis, perhaps due to expression of p53 or hypo-phosphorylated Rb.

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References

  • Ahne B, Stratling WH . 1994 J. Biol. Chem. 269: 17794–17801

  • Akashi K, Traver D, Miyamoto T, Weissman IL . 2000 Nature 404: 193–197

  • Anderson KL, Smith KA, Perkin H, Hermanson G, Anderson CG, Jolly DJ, Maki RA, Torbett BE . 1999 Blood 94: 2310–2318

  • Andrews NC, Kotkow KJ, Ney PA, Eerdjument BH, Tempst P, Orkin SH . 1993 Proc. Natl. Acad. Sci. USA 90: 11488–11492

  • Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG . 1996 Genomics 35: 30–38

  • Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M . 1994 Nature 370: 226–229

  • Bae SC, Yamaguchi-Iwai Y, Ogawa E, Maruyama M, Inuzuka M, Kagoshima H, Shigesada K, Satake M, Ito Y . 1993 Oncogene 8: 809–814

  • Barberis A, Super-Furga G, Busslinger M . 1987 Cell 50: 347–359

  • Bassuk AG, Leiden JM . 1995 Immunity 3: 223–237

  • Bavisotto L, Kaushansky K, Lin N, Hromas R . 1991 J. Exp. Med. 174: 1097–1101

  • Behre G, Whitmarsh AJ, Coghlan MP, Hoang T, Carpenter CL, Zhang DE, Davis RJ, Tenen DG . 1999a J. Biol. Chem. 274: 4939–4946

  • Behre G, Smith LT, Carpenter CL, Hiddemann W, Friedman AD, Tenen DG . 1999b Blood 94: 684a

  • Bellon T, Perrotti D, Calabretta D . 1998 Blood 90: 1828–1839

  • Bergh G, Ehinger M, Olsson I, Jacobsen SEW, Gullberg U . 1999 Blood 94: 1971–1978

  • Biedenkapp H, Borgemeyer U, Sippel AE, Klempnauer KH . 1988 Nature 335: 835–837

  • Bies J, Mukhopadhyaya R, Pierce J, Wolff L . 1995 Cell Growth Differ. 6: 59–68

  • Bourette RP, Rohrschneider LR . 2000 Growth Factors 17: 155–166

  • Britos-Bray M, Friedman AD . 1997 Mol. Cell. Biol. 17: 5127–5135

  • Bromleigh VC, Freedman LP . 2000 Genes Dev. 14: 2581–2586

  • Calkhoven CF, Muller C, Leutz A . 2000 Genes Dev. 14: 1920–1932

  • Canman CE, Gilmer TM, Coutts SB, Kastan MB . 1995 Genes Dev. 9: 600–611

  • Cao W, Britos-Bray M, Claxton DF, Kelley CA, Speck NA, Liu PP, Friedman AD . 1997 Oncogene 15: 1315–1327

  • Cao W, Adya N, Britos-Bray M, Liu PP, Friedman AD . 1998 J. Biol. Chem. 273: 31534–31540

  • Carlsson L, Candeias S, Staerz U, Keller G . 1995 Eur. J. Immunol. 25: 2308–2317

  • Castilla LH, Garrett L, Adya N, Orlic D, Dutra A, Anderson S, Owens J, Eckhaus M, Bodine D, Liu PP . 1999 Nature Genet. 23: 144–146

  • Catt D, Hawkins S, Roman A, Luo W, Skalnik DG . 1999 Blood 94: 3151–3160

  • Chang CP, Brocchieri L, Shen WF, Largman C, Cleary ML . 1996 Mol. Cell. Biol. 16: 1734–1745

  • Chang DH, Angelin-Duclos C, Calame K . 2000 Nat. Immunol. 1: 169–176

  • Chen HM, Pahl HL, Scheibe RJ, Zhang DE, Tenen DG . 1993 J. Biol. Chem. 268: 8230–8239

  • Chen HM, Zhang P, Voso MT, Hohaus S, Gonzalez DA, Glass CK, Zhang DE, Tenen DG . 1995a Blood 85: 2918–2928

  • Chen H, Ray-Gallet D, Zhang P, Hetherington CJ, Gonzalez DA, Zheng DE, Moreau-Gachelin F, Tenen DG . 1995b Oncogene 11: 1549–1560

  • Chen PL, Riley DJ, Chen-Kiang S, Lee WH . 1996 Proc. Natl. Acad. Sci. USA 93: 465–469

  • Chen SS, Chen JF, Johnson PF, Muppala V, Lee YH . 2000 Mol. Cell. Biol. 20: 7292–7299

  • Cheng T, Shen H, Giokas D, Gere J, Tenen DG, Scadden DT . 1996 Proc. Natl. Acad. Sci. USA 93: 13158–13163

  • Chiang MY, Monroe JG . 2001 J. Immunol. 166: 6091–6098

  • Chih DY, Chumakov AM, Park DJ, Silla AG, Koeffler HP . 1997 Blood 90: 2987–2994

  • Chiu R, Angel P, Karin M . 1989 Cell 59: 979–986

  • Christensen JE, Andreasen SO, Christensen JP . 2001 Int. Immunol. 13: 593–600

  • Christy RJ, Kaestner KH, Geiman DE, Lane MD . 1993 Proc. Natl. Acad. Sci. USA 88: 2593–2597

  • Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP . 1997 Mol. Cell. Biol. 17: 1375–1386

  • Chylicki K, Ehinger M, Svedberg H, Gullberg U . 2000 Cell Growth Differ. 11: 561–571

  • Collins SJ, Ulmer J, Purton LE, Darlington G . 2001 Blood 98: 2382–2388

  • Cooper C, Henderson A, Artandi S, Avitahl N, Calame K . 1995 Nucl. Acids Res. 23: 4371–4377

  • Corsetti MT, Calabi F . 1997 Blood 89: 2359–2368

  • Crosby SD, Puetz JJ, Simburger KS, Fahrner TJ, Milbrandt J . 1991 Mol. Cell. Biol. 11: 3835–3841

  • Dash AB, Orrico FC, Ness SA . 1999 Genes Dev. 10: 1858–1869

  • de Groot R, Auwerx J, Karperien M, Staels B, Kruijer W . 1991 Nucl. Acids Res. 19: 775–781

  • De Koning JP, Soede-Bobok AA, Ward AC, Schelen AM, Antonissen C, van Leeuwen D, Lowenberg B, Touw IP . 2000 Oncogene 19: 3290–3298

  • DeKoter RP, Singh H . 2000 Science 288: 1439–1441

  • DeKoter RP, Walsh JC, Singh H . 1998 EMBO J. 17: 4456–4468

  • Descombes P, Schibler U . 1991 Cell 67: 569–580

  • de The H, Marchio A, Tiollais P, Dejean A . 1989 EMBO J. 8: 429–433

  • Drummond IA, Rupprecht HD, Rohwer-Nutter P, Lopez-Guisa J, Maddel SL, Rauscher FJ, Sukhatme VP . 1994 Mol. Cell. Biol. 14: 3800–3809

  • Du J, Savage MP, DeKoter R, McKercher SR, Maki R, Singh H, Ackerman SJ . 1998 Blood 92: 191a

  • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G . 1997 Cell 89: 747–754

  • Ehinger M, Bergh G, Johnsson E, Baldetorp B, Olsson I, Gullberg U . 1998 Exp. Hematol. 26: 1043–1052

  • Eisenbeis CF, Singh H, Storb U . 1995 Genes Dev. 9: 1377–1387

  • Eklund EA, Kakar R . 1999 J. Immunol. 163: 6095–6105

  • Eklund EA, Jalava A, Kakar R . 2000 J. Biol. Chem. 275: 20117–20126

  • Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K . 1999 J. Cell. Biol. 145: 1049–1061

  • Erickson P, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin H . 1996 Blood 88: 1813–1823

  • Faust N, Bonifer C, Sippel AE . 1999 DNA Cell Biol. 18: 631–642

  • Fisher RC, Olson MC, Pongubala JM, Perkel JM, Atchinson ML, Scott EW, Simon MC . 1998 Mol. Cell. Biol. 18: 4347–4357

  • Ford AM, Bennett CA, Healy LE, Towatari M, Greaves MF, Enver T . 1996 Proc. Natl. Acad. Sci. USA 93: 10838–10843

  • Friedman AD, Landschulz WH, McKnight SL . 1989 Genes Dev. 3: 1314–1322

  • Friedman AD, McKnight SL . 1990 Genes Dev. 4: 1416–1426

  • Friedman AD . 1996a Curr. Topics Microb. Immun. 211: 149–158

  • Friedman AD . 1996b Cancer Res. 56: 3250–3256

  • Friedman AD . 1999 Leukemia 13: 1932–1942

  • Gaboli M, Kotsi PA, Gurrieri C, Cattoretti G, Ronchetti S, Cordon-Cardo C, Broxmeyer HE, Hromas R, Pandolfi PP . 2001 Genes Dev. 15: 1625–1630

  • Goethe R, Loc PV . 1994 J. Biol. Chem. 269: 31302–31309

  • Golay J, Capucci A, Arsura M, Castellano M, Rizzo V, Introna M . 1991 Blood 77: 149–158

  • Gombart AF, Shiohara M, Kwok SH, Agematsu K, Komiyama A, Koeffler HP . 2001 Blood 97: 2561–2567

  • Habener JF, Ron D . 1992 Genes Dev. 6: 439–453

  • Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE . 1991 Proc. Natl. Acad. Sci. USA 88: 9618–9622

  • Hagemeier C, Bannister AJ, Cook A, Kouzarides T . 1993 Proc. Natl. Acad. Sci. USA 90: 1580–1584

  • Hegde SP, Kumar A, Kurschner C, Shapiro LH . 1998 Mol. Cell. Biol. 18: 2729–2737

  • Hegde SP, Zhao J, Ashmun RA, Shapiro LH . 1999 Blood 94: 1578–1589

  • Henkel GW, McKercher SR, Leenen PJ, Maki RA . 1999 Blood 93: 2849–2858

  • Herzer U, Crocoll A, Barton D, Howells N, Englert C . 1999 Curr. Biol. 9: 837–840

  • Hetherington CJ, Kingsley PD, Crocicchio F, Zhang P, Rabin MS, Palis J, Zhang DE . 1999 J. Immunol. 162: 503–509

  • Heydemann A, Juan G, Hennessy K, Parmacek MS, Simon MC . 1996 Mol. Cell. Biol. 16: 1676–1686

  • Hohaus S, Petrovick MS, Voso MT, Sun Z, Zhang DE, Tenen DG . 1995 Mol. Cell. Biol. 15: 5830–5845

  • Holtschke T, Lohler J, Kanno Y, Fehr T, Giese N, Rosenbauer F, Lou J, Knobeloch KP, Gabriele L, Waring JF, Bachmann MF, Zinkernagel RM, Morse III HC, Ozato K, Horak I . 1996 Cell 87: 307–317

  • Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'hara P, Hagen FS, Kaushanksky K . 1991 J. Biol. Chem. 266: 14183–14187

  • Hu HM, Baer M, Williams SC, Johnson PF, Schwartz RC . 1998 J. Immunol. 160: 2334–2342

  • Inoue K, Tamaki H, Ogawa H, Oka Y, Soma T, Tatekawa T, Oji Y, Tsuboi A, Kim EH, Kawakami M, Akiyama T, Kishimoto T, Sugiyama H . 1998 Blood 91: 2969–2976

  • Jochum W, Passegue E, Wagner F . 2001 Oncogene 20: 2401–2412

  • Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG . 2001 Mol. Cell. Biol. 21: 3789–3806

  • Jones LC, Lin ML, Chen SS, Krug U, Hofmann WK, Lee S, Lee YH, Koeffler HP . 2002 Blood 99: 2032–2036

  • Kastan MB, Radin AI, Kuerbitz SJ, Onyekwere O, Wolkow CA, Civin CI, Stone KD, Woo T, Ravindranath Y, Craig RW . 1991 Cancer Res. 51: 4279–4286

  • Kataoka K, Fujiwara KT, Noda M, Nishizawa M . 1994a Mol. Cell. Biol. 14: 7581–7591

  • Kataoka K, Noda M, Nishizawa M . 1994b Mol. Cell. Biol. 14: 700–712

  • Kataoka K, Noda M, Nishizawa M . 1996 Oncogene 12: 53–62

  • Kelly LM, Englmeier U, Lafon I, Sieweke MH, Graf T . 2000 EMBO J. 19: 1987–1997

  • Kerppola TK, Curran TK . 1994 Oncogene 9: 675–684

  • Khanna-Gupta A, Zibello T, Kolla S, Neufeld EJ, Berliner N . 1997 Blood 90: 2784–2795

  • Khanna-Gupta A, Zibello T, Simkevich C, Rosmarin AG, Berliner N . 2000 Blood 95: 3734–3741

  • Khanna-Gupta A, Zibello T, Sun H, Lekstrom-Himes J, Berliner N . 2001 Proc. Natl. Acad. Sci., USA 98: 8000–8005

  • Klemsz MJ, McKercher SR, Celada A, Van Beveran C, Maki RA . 1990 Cell 61: 113–124

  • Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T . 1997 Cell 89: 755–764

  • Kondo M, Scherer DC, Miyamoto T, King AG, Akashi K, Sugamura K, Weissman IL . 2000 Nature 407: 383–386

  • Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R . 1993 Cell 74: 679–691

  • Krishnaraju K, Nguyen HQ, Liebermann DA, Hoffman B . 1995 Mol. Cell. Biol. 15: 5499–5507

  • Krishnaraju K, Hoffman B, Liebermann DA . 1998 Blood 92: 1957–1966

  • Krishnaraju K, Hoffman B, Liebermann DA . 2001 Blood 97: 1298–1305

  • Kulessa H, Frampton J, Graf T . 1995 Genes Dev. 9: 1250–1262

  • Labrecque J, Allan D, Chambon P, Iscove NN, Lohnes D, Hoang T . 1998 Blood 92: 607–615

  • Lacaud G, Carlsson L, Keller G . 1998 Immunity 9: 827–838

  • Lagasse E, Weissman IL . 1997 Cell 89: 1021–1031

  • Landschulz WH, Johnson PF, McKnight SL . 1989 Science 246: 1681–1688

  • Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C . 1995 Exp. Hematol. 23: 1160–1166

  • Lawson ND, Khanna-Gupta A, Berliner N . 1998 Blood 91: 2517–2524

  • LeCouter JE, Kablar B, Hardy WR, Ying C, Megeney LA, May LL, Rudnicki MA . 1998 Mol. Cell. Biol. 18: 7455–7465

  • Lee EY, Chang CY, Wang YC, Lai CC, Herrup K, Lee WH, Bradley A . 1992 Nature 359: 288–294

  • Lee SL, Wang Y, Milbrandt J . 1996 Mol. Cell. Biol. 16: 4566–4572

  • Lekstrom-Himes JA, Dorman SE, Dopar P, Holland SM, Gallin JI . 1999 J. Exp. Med. 189: 1847–1852

  • Levanon D, Negreanu V, Bernstein Y, Bar-Am I, Avivi L, Groner Y . 1994 Genomics 23: 425–432

  • Li AC, Guidez FRB, Collier JG, Glass CK . 1998 J. Biol. Chem. 273: 5389–5399

  • Li J, King I, Sartorelli AC . 1994 Cell Growth Differ. 5: 743–751

  • Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler KJ, Basu S, Zhan YF, Dunn AR . 1994 Blood 84: 1737–1746

  • Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC . 1996a Cell 5: 491–501

  • Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP . 1996b Genes Dev. 10: 142–153

  • Liu F, Poursine-Laurent J, Wu HY, Link DC . 1997 Blood 90: 2583–2590

  • Loeb DM, Friedman AD, Sukumar SV . 2000 Blood 96: 284a

  • Lord KA, Abdollahi A, Hoffman-Liebermann B, Liebermann DA . 1993 Mol. Cell. Biol. 13: 841–851

  • Lou J, Cao W, Bernardin F, Ayyanathan K, Rauscher III FJ, Friedman AD . 2000 Oncogene 19: 2695–2703

  • Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T . 1993 Nature 362: 847–849

  • Luo W, Skalnik DG . 1996 J. Biol. Chem. 271: 18203–18210

  • Lutz PG, Houzel-Charavel A, Moog-Lutz C, Cayre YE . 2001 Blood 97: 2449–2456

  • Manz MG, Traver D, Miyamoto T, Weissman IL, Akashi K . 2001 Blood 97: 3333–3341

  • Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD . 1999 Mol. Cell. Biol. 19: 3635–3644

  • Marecki S, Riendeau CJ, Liang MD, Fenton MJ . 2001 J. Immunol. 166: 6829–6838

  • Martinelli R, Blandino G, Scardigli R, Crescenzi M, Lombardi D, Sacchi A, Soddu S . 1997 Oncogene 15: 607–611

  • Maurer U, Brieger J, Weidmann E, Mitrou PS, Hoelzer D, Bergmann L . 1997 Exp. Hematol. 25: 945–950

  • McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH . 1997 Proc. Natl. Acad. Sci. USA 94: 6781–6785

  • McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA . 1996 EMBO J. 15: 5647–5658

  • Meraro D, Hashmueli S, Koren B, Azriel A, Oumard A, Kirchoff S, Hauser N, Nagulapalli S, Atchinson ML, Levi BZ . 1999 J. Immunol. 163: 6468–6478

  • Meyers S, Downing JR, Hiebert SW . 1993 Mol. Cell. Biol. 13: 6336–6345

  • Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF . 1993 J. Biol. Chem. 268: 20110–20115

  • Montecino-Rodriguez E, Leathers H, Dorshkind K . 2001 Nature Immunol. 2: 83–88

  • Morris JF, Hromas R, Rauscher FJ . 1994 Mol. Cell. Biol. 14: 1786–1795

  • Morris JF, Rauscher JF, Davis P, Klemsz M, Xu D, Tenen D, Hromas R . 1995 Blood 86: 3640–3647

  • Moulton KS, Semple K, Wu H, Glass CK . 1994 Mol. Cell. Biol. 14: 4408–4418

  • Mucenski ML, McClain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott WJ, Potter SS . 1991 Cell 65: 677–689

  • Muller C, Kowenz-Leutz E, Grieser-Ada S, Graf T, Leutz A . 1995 EMBO J. 14: 6127–6135

  • Naar AM, Boutin JM, Lipkin SM, Yu VC, Holloway JM, Glass CK, Rosenfeld MG . 1991 Cell 65: 1267–1279

  • Nakajima H, Ihle N . 2001 Blood 98: 897–905

  • Nerlov C, McNagny KM, Doderlein G, Kowentz-Leutz E, Graf T . 1998 Genes Dev. 12: 2413–2422

  • Ness SA, Kowentz-Leutz E, Casini T, Graf T, Leutz A . 1993 Genes Dev. 7: 749–759

  • Nguyen HQ, Hoffman-Liebermann B, Liebermann DA . 1993 Cell 72: 197–209

  • Niki M, Okada H, Takano H, Kujo J, Tani K, Hibino H, Asano S, Ito Y, Satake M, Noda T . 1997 Proc. Natl. Acad. Sci. USA. 94: 5697–5702

  • Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S, Friedman AD . 1994 Mol. Cell. Biol. 14: 5558–5568

  • Nuchprayoon I, Simkevich CP, Menglin L, Friedman AD, Rosmarin AD . 1997 Blood 89: 4546–4554

  • Nuchprayoon I, Simkevich CP, Luo M, Rosmarin AG, Friedman AD . 1999 J. Biol. Chem. 274: 1085–1091

  • Oelgeschlager M, Nuchprayoon I, Luscher B, Friedman AD . 1996 Mol. Cell. Biol. 16: 4717–4725

  • Ogata K, Hojo H, Aimoto S, Nakai T, Nakamura H, Sarai A, Ishii S, Nishimura Y . 1992 Proc. Natl. Acad. Sci. USA 89: 6428–6432

  • Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y . 1993a Proc. Natl. Acad. Sci. USA 90: 6859–6863

  • Ogawa E, Inuzuka M, Maruyamna M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K . 1993b Virol. 194: 314–331

  • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR . 1996 Cell 84: 321–330

  • Olson MC, Scott EW, Hack AA, Su GH, Tenen DG, Singh H, Simon MC . 1995 Immunity 3: 703–714

  • Pahl HL, Scheibe RJ, Zhang DE, Chen HM, Galson DL, Maki RA, Tenen DG . 1993 J. Biol. Chem. 268: 5014–5020

  • Pan Z, Hetherington CJ, Zhang DE . 1999 J. Biol. Chem. 274: 23242–23248

  • Park DJ, Chumakov A, Vuong P, Chih D, Gombart A, Miller Jr WH, Koeffler HP . 1999 J. Clin. Invest. 103: 1399–1408

  • Peters UR, Tschan MP, Kreuzer KA, Baskaynak G, Lass U, Tobler A, Fey MF, Schmidt CA . 1999 Cancer Res. 59: 4233–4236

  • Petrovick MS, Hiebert SW, Friedman AD, Hetherington CJ, Tenen DG, Zhang DE . 1998 Mol. Cell. Biol. 18: 3915–3925

  • Passegue E, Jochum W, Schorpp-Kistner M, Mohle-Steinlein U, Wagner EF . 2001 Cell 104: 21–32

  • Querfurth E, Schuster M, Kulessa H, Crispino JD, Doderlien G, Orkin SH, Graf T, Nerlov C . 2000 Genes Dev. 14: 2515–2525

  • Radomska HS, Huettner CS, Zhang P, Tenen DG . 1998 Mol. Cell. Biol. 18: 4301–4314

  • Rauscher FJ, Morris JF, Tournary OE, Cook DM, Curran T . 1990 Science 250: 1259–1262

  • Reiss K, Travali S, Calabretta B, Baserga R . 1991 J. Cell Physiol. 148: 338–343

  • Rekhtman N, Radparvar F, Evans T, Skoultchi AI . 1999 Genes Dev. 13: 1398–1411

  • Rodel JE, Link DC . 1996 Blood 87: 1309–1312

  • Roodman GD . 1996 Endocr. Rev. 17: 308–332

  • Rosmarin AG, Caprio D, Levy R, Simkevich C . 1995a Proc. Natl. Acad. Sci. USA 92: 801–805

  • Rosmarin AG, Caprio DG, Kirsch DG, Handa H, Simkevich CP . 1995b J. Biol. Chem. 270: 23627–23633

  • Rosmarin AG, Luo M, Caprio DG, Shang J, Simkevich CP . 1998 J. Biol. Chem. 273: 13097–13103

  • Saffer JD, Jackson SP, Annarella MB . 1991 Mol. Cell. Biol. 11: 2189–2199

  • Sasaki K, Yagi H, Bronson RT, Tominaga K, Matsunashi T, Deguchi K, Tani Y, Kishimoto T, Komori T . 1996 Proc. Natl. Acad. Sci. USA 93: 12359–12363

  • Satake M, Inuzuka M, Shigesada K, Oikawa T, Ito Y . 1992 Jpn. J. Can. Res. 83: 714–722

  • Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowsak WH, Reid DS, Largman C, Lawrence JH, Humphries RK . 1994 Proc. Natl. Acad. Sci. USA 91: 12223–12227

  • Schreiber M, Kolbus A, Piu F, Szabowski A, Mohle-Steinlein U, Tian J, Karin M, Angel P, Wagner E . 1999 Genes Dev. 13: 607–619

  • Schutte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J . 1989 Cell 59: 987–997

  • Scott LM, Civin CI, Rorth P, Friedman AD . 1992 Blood 80: 1725–1735

  • Scott EW, Simon MC, Anastasi J, Singh H . 1994 Science 265: 1573–1577

  • Screpanti I, Romani L, Musiani P, Modesti A, Fattori E, Lazzaro D, Sellito C, Scarpa S, Bellavia D, Lattanzio G, Bistoni F, Frati L, Cortese R, Gulino A, Ciliberto G, Coslantini F, Poli V . 1995 EMBO J. 14: 1932–1941

  • Seymour JF, Lieschke GJ, Grail D, Quilici C, Hodgson G, Dunn AR . 1997 Blood 90: 3037–3049

  • Shapiro LH . 1995 J. Biol. Chem. 270: 8763–8771

  • Sheiness D, Gardinier M . 1984 Mol. Cell. Biol. 4: 1206–1212

  • Shimozaki K, Nakajima K, Hirano T, Nagata S . 1997 J. Biol. Chem. 272: 25184–25189

  • Sieweke MH, Tekotte H, Frampton J, Graf T . 1996 Cell 85: 49–60

  • Skalnik DG, Strauss EC, Orkin SH . 1991 J. Biol. Chem. 266: 16376–16744

  • Slomiany BA, D'Arigo KL, Kelly MM, Kurtz DT . 2000 Mol. Cell. Biol. 20: 5986–5997

  • Smith LT, Hohaus S, Gonzalez DA, Dziennis SE, Tenen DG . 1996 Blood 88: 1234–1247

  • Smith SI, Weil D, Johnson GR, Boyd AW, Li CL . 1998 Blood 91: 764–773

  • Soddu S, Blandino G, Scardigli R, Martinelli R, Rizzo MG, Crescenzi M, Sacchi A . 1996 Mol. Cell. Biol. 16: 487–495

  • Strom DK, Nip J, Westendorf JJ, Linggi B, Lutterbach B, Downing JR, Lenny N, Hiebert SW . 2000 J. Biol. Chem. 275: 3438–3445

  • Suzow J, Friedman AD . 1993 Mol. Cell. Biol. 13: 2141–2151

  • Szabo E, Preis LH, Birrer MJ . 1994 Cell Growth Differ. 5: 439–446

  • Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K . 2000 Immunity 13: 155–165

  • Tanaka T, Akira S, Yoshida M, Umemoto Y, Yoneda N, Shirafuji H, Suematsu S, Yoshida N, Kishimoto T . 1995 Cell 80: 353–361

  • Tanaka T, Yoshida N, Kishimoto T, Akira S . 1997 EMBO J. 16: 7432–7443

  • Tavner FJ, Simpson R, Tashiro S, Favier D, Jenkins NA, Gilbert DJ, Copeland NG, Macmillan EM, Lutwyche J, Keough RA, Ishii S, Gonda TJ . 1998 Mol. Cell. Biol. 18: 989–1002

  • Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK . 1997 Mol. Cell. Biol. 17: 495–505

  • Timchenko NA, Wilde M, Darlington GJ . 1999 Mol. Cell. Biol. 19: 2936–2945

  • Trauth K, Mutschler B, Jenkins NA, Gilbert DJ, Copeland NG, Klempnauer KH . 1994 EMBO J. 13: 5994–6005

  • Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Askashi K, Weissman IL . 2001 Blood 98: 627–635

  • Tsai S, Collins SJ . 1993 Proc. Natl. Acad. Sci. USA 90: 7153–7157

  • Tsai FY, Browne CP, Orkin SH . 1998 Dev. Biol. 196: 218–227

  • Umek RH, Friedman AD, McKnight SL . 1991 Science 25: 288–292

  • Umesano K, Murakami KK, Thompson CC, Evans RM . 1991 Cell 65: 1255–1266

  • van Damm HH, Duyndam M, Rottier R, Bosch A, de Vries-Smits L, Herrlich P, Zantema A, Angel P, van der Eb . 1993 EMBO J. 12: 479–487

  • van Dijk TB, Caldenhoven E, Raaijmakers JA, Lammer JW, Koendeerman L, De Groot RP . 1998 Blood 91: 2126–2132

  • Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA . 1993 Mol. Cell. Biol. 13: 3324–3339

  • Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA . 1996a Proc. Natl. Acad. Sci. USA 93: 3444–3449

  • Wang Q, Stacy T, Miller JD, Lewis AF, Gu T-L, Huang X, Bushweller JH, Bories J-C, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marin-Padilla M, Sharpe AH, Speck NA . 1996b Cell 87: 697–708

  • Wang X, Scott E, Sawyers CL, Friedman AD . 1999 Blood 94: 560–571

  • Wang W, Wang X, Ward AC, Touw IP, Friedman AD . 2001 Leukemia 15: 779–786

  • Wang Q, Friedman AD . 2002 Blood 99: in press

  • Ward AC, Loeb DM, Soede-Bobok AA, Touw I, Friedman AD . 2000 Leukemia 14: 973–990

  • Weinberg RA . 1995 Cell 81: 323–330

  • Westendorf JJ, Yamamoto CM, Lenny N, Downing JR, Selsted ME, Hiebert SW . 1998 Mol. Cell. Biol. 18: 322–333

  • Weston K, Bishop MJ . 1989 Cell 58: 85–93

  • Williamson E, Xu HN, Gombart AF, Verbeek W, Chumakov AM, Friedman AD, Koeffler HP . 1998 J. Biol. Chem. 273: 14796–14808

  • Yamaguchi Y, Nishio H, Kishi K, Ackerman SJ, Suda T . 1999 Blood 94: 1429–1439

  • Yamanaka R, Barlow C, Lekstrom-Himes J, Castilla LH, Liu PP, Eckhaus M, Decker T, Wynshaw-Boris A, Xanthopolous KG . 1997 Proc. Natl. Acad. Sci. USA 94: 13187–13192

  • Zhang DE, Hetherington CJ, Chen HM, Tenen DG . 1994a Mol. Cell. Biol. 14: 373–381

  • Zhang DE, Fujioka KI, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DG . 1994b Mol. Cell. Biol. 14: 8085–8095

  • Zhang DE, Hetherington CJ, Tan S, Dziennis SE, Gonzalez DA, Chen HM, Tenen DG . 1994c J. Biol. Chem. 269: 11425–11434

  • Zhang DE, Hetherington CJ, Meyer S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW, Tenen DG . 1996a Mol. Cell. Biol. 16: 1231–1240

  • Zhang P, Benson GV, Rhoades KL, Maas RL, Tenen DG . 1996b Blood 88: 631a

  • Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG . 1997 Proc. Natl. Acad. Sci. USA 94: 569–574

  • Zhang P, Iwama A, Datta MW, Darlington GJ, Link DC, Tenen DG . 1998 J. Exp. Med. 188: 1173–1184

  • Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH, Tenen DG . 2000 Blood 96: 2641–1648

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Acknowledgements

AD Friedman is a Scholar of the Leukemia and Lymphoma Society and his research is supported by the Children's Cancer Foundation.

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  1. Division of Pediatric Oncology, Johns Hopkins University, Baltimore, 21231, Maryland, MD, USA

    Alan D Friedman

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Friedman, A. Transcriptional regulation of granulocyte and monocyte development. Oncogene 21, 3377–3390 (2002). https://doi.org/10.1038/sj.onc.1205324

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