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Allografting

The early referral for reduced-intensity stem cell transplantation in patients with Ph1 (+) chronic myelogenous leukemia in chronic phase in the imatinib era: results of the Latin American Cooperative Oncohematology Group (LACOHG) prospective, multicenter study

Bone Marrow Transplantation volume 36, pages 1043–1047 (2005)Cite this article

Summary:

Using a reduced-intensity stem cell transplantation (RIST) schedule, 24 patients with Philadelphia (Ph1) (+) chronic myelogenous leukemia (CML) in first chronic phase (CP) were prospectively allografted in four Latin American countries: México, Brazil, Colombia and Venezuela, using HLA-identical siblings as donors. The median age of the patients was 41 years (range 10–71 years); there were eight females. Patients received a median of 4.4 × 106/kg CD34 cells. The median time to achieve above 0.5 × 109/l granulocytes was 12 days, range 0–41 days, and the median time to achieve above 20 × 109/l platelets was also 12 days, range 0–45 days. In all, 22 patients are alive 81–830 (median 497) days after RIST. The 830-day probability of survival is 92%, and the median survival has not been reached, being beyond 830 days. A total of 11 patients (46%) developed acute graft-versus-host disease (GVHD), and seven of 23 (30%) developed chronic GVHD. Two patients died 43 and 210 days after RIST, one as a result of sepsis and the other of chronic GVHD. The 100-day mortality was 4.4%, and transplant-related mortality was 8%. RIST for patients with CML in CP appears to be an adequate therapeutic option.

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Authors and Affiliations

  1. Centro de Hematología y Medicina Interna de Puebla, Puebla, México

    G J Ruiz-Argüelles, A Morales-Toquero & C Manzano

  2. Laboratorios Clínicos de Puebla, Puebla, México

    G J Ruiz-Argüelles

  3. Hospital Universitario de Monterrey, Monterrey, México

    D Gómez-Almaguer & C H Gutiérrez-Aguirre

  4. Centro Médico La Raza, Instituto Mexicano del Seguro Social, México City, México

    J Vela-Ojeda & M A García-Ruiz-Esparza

  5. Instituto de Cancerología, Clínica Las Américas, Medellín, Colombia

    A Karduss

  6. Universidad de Carabobo, Valencia, Venezuela

    A Sumoza

  7. Universidad de Campinas, Sao Paulo, Brazil

    C de-Souza & E Miranda

  8. MD Anderson Cancer Center, Houston, TX, USA

    S Giralt

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  1. G J Ruiz-Argüelles
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  2. D Gómez-Almaguer
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  12. S Giralt
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Correspondence to G J Ruiz-Argüelles.

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Ruiz-Argüelles, G., Gómez-Almaguer, D., Morales-Toquero, A. et al. The early referral for reduced-intensity stem cell transplantation in patients with Ph1 (+) chronic myelogenous leukemia in chronic phase in the imatinib era: results of the Latin American Cooperative Oncohematology Group (LACOHG) prospective, multicenter study. Bone Marrow Transplant 36, 1043–1047 (2005). https://doi.org/10.1038/sj.bmt.1705190

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