Abstract
To evaluate prostate cancer (PCa) detection after repeated negative saturation biopsy, 75 patients, aged 53–78 years, underwent transurethral resection of prostate (TURP) because of persistent suspicion of cancer; median PSA was 11.8 ng ml−1 and 58 men complained lower urinary tract symptoms (LUTS). In 12 (16%) and 3 (4%) men a T1a and T1b PCa was found with median PSA and Gleason score equal to 14.2 vs 23.6 ng ml−1 and 5.6 vs 7 ng ml−1. In case of persistent suspicion of PCa after repeated negative saturation biopsy, TURP may be proposed, aside from the coexistence of LUTS, to rule out a PCa, in younger patients with high PSA values (⩾20 ng ml−1).
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References
Freedland SJ, Partin AW . Prostate specific antigen: update. Urology 2006; 67: 458–460.
Ravery V, Goldblatt L, Royer B, Blanc E, Toublanc M, Boccon-Gibod L . Extensive biopsy protocol improves the detection rate of prostate cancer. J Urol 2000; 164: 393–396.
Puppo P, Introini C, Calvi P, Naselli A . Role of transurethral resection of the prostate and biopsy of the peripheral zone in the same session after repeated negative biopsies in the diagnosis of prostate cancer. Eur Urol 2006; 49: 873–878.
Aragona F, Pepe P, Motta M, Saita A, Raciti G, La Rosa P et al. Incidence of prostate cancer in Sicily: results of a multicenter case-findings protocol. Eur Urol 2005; 47: 569–574.
Hodge KK, McNeal JE, Terris MK, Stamey TA . Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate. J Urol 1989; 142: 71–75.
Norberg M, Egevad L, Holberg L, Sparen P, Norlen BJ, Busch C . The sextant protocol for ultrasound-guided core biopsies of prostate underestimates the presence of cancer. Urology 1997; 50: 562–566.
Pepe P, Aragona F . Prostate needle biopsy: 12 vs 18 cores Is it necessary? Urol Int 2005; 74: 19–22.
Jones JS, Patel A, Schoefield L, Rabets JC, Zippe CD, Magi-Galluzzi C . Saturation technique does not improve cancer detection as an initial prostate biopsy strategy. J Urol 2006; 175: 485–488.
Pepe P, Aragona F . Saturation prostate needle biopsy and prostate cancer detection at initial and repeat evaluation. Urology 2007; 70: 1131–1135.
Yanke BV, Gonen M, Scardino PT, Kattan MW . Validation of nomogram for predicting positive repeat biopsy for prostate cancer. J Urol 2005; 173: 421–424.
Scattoni V, Roscigno M, Freschi M, Dehò F, Raber M, Briganti A et al. Atypical small acinar proliferation (ASAP) on extended prostatic biopsies: predictive factors of cancer detection on repeat biopsies. Arch Ital Urol Androl 2005; 77: 31–36.
Djavan B, Milani S, Remzi M . Prostate biopsy: who, how and when. An update. Can J Urol 2005; 1: 44–48.
Campos-Fernandes JL, Bastien L, Nicolaiew M, Robert G, Terry S, Vacherot F et al. Prostate cancer detection rate in patients with repeated extended 21-sample needle biopsy. Eur Urol 2009; 55: 600–609.
Philip J, Hanchanale V, Foster CS, Javlè P . Importance of peripheral biopsies in maximising the detection of early prostate cancer in repeat 12-core biopsy protocol. BJU Int 2006; 98: 559–562.
Singh H, Canto EI, Shariat SF, Kadmon D, Miles BJ, Wheeler TM et al. Predictors of prostate cancer after initial negative systematic 12 core biopsy. J Urol 2004; 171: 1850–1854.
Fleshner N, Klotz L . Role of ‘saturation biopsy’ in the detection of prostate cancer among difficult diagnostic cases. Urology 2002; 60: 93–97.
Walz J, Graefen M, Chun FK, Erbersdobler A, Haese A, Steuber T et al. High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series. Eur Urol 2006; 50: 498–505.
Rabets JC, Jones JS, Patel A, Zippe CD . Prostate cancer detection with office based saturation biopsy in a repeat biopsy population. J Urol 2004; 172: 94–97.
Rodriguez Alonso A, Gonzalez Blanco A, Pita Fernandez S, Suarez Pascual G, Bonelli Martìn C, Lorenzo Franco J et al. Prostate cancer diagnosis using 24 cores extended biopsy. Actas Urol Esp 2005; 29: 934–942.
Jones JS, Oder M, Zippe CD . Saturation prostate biopsy with periprostatic block can be performed in office. J Urol 2002; 168: 2108–2110.
Eskicorapci SY, Guliyev F, Islamoglu E, Eregen A, Ozen H . The effect of prior biopsy scheme on prostate cancer detection for repeat biopsy population: results of the 14-core prostate biopsy technique. Int Urol Nephrol 2007; 39: 189–195.
Pelzer AE, Bektic J, Berger AP, Halpern EJ, Koppelstätter F, Klauser A et al. Are transition zone biopsies still necessary to improve prostate cancer detection? Results from the Tyrol screening project. Eur Urol 2005; 48: 916–921.
Miyake H, Kurahashi T, Muramaki M, Yamanak K, Hara I . Significance of routine transition biopsies in Japanese men undergoing transrectal ultrasound-guided prostate biopsies. Int J Urol 2005; 12: 964–968.
Radhakrishnan S, Dorkin TJ, Sheikh N, Greene DR . Role of transition zone sampling by TURP in patients with raised PSA and multiple negative transrectal ultrasound-guided prostatic biopsies. Prostate Cancer Prostatic Dis 2004; 7: 338–342.
Zigeuner R, Schips L, Lipsky K, Auprich M, Salfellner M, Rehak P et al. Detection of prostate cancer by TURP or open surgery in patients with previously negative transrectal prostate biopsies. Urology 2003; 62: 883–887.
van Renterghem K, Van Koeveringe G, Achten R, Van Kerrebroeck P . Clinical relevance of transurethral resection of the prostate in ‘asymptomatic’ patients with an elevated prostate-specific antigen level. Eur Urol 2007; 52: 819–826.
Sakai I, Harada K, Kurahashi T, Yamanaka K, Hara I, Miyake H . Analysis of differences in clinicopathological features between prostate cancers located in the transition and peripheral zones. Int J Urol 2006; 13: 368–372.
Capitanio U, Scattoni V, Freschi M, Briganti A, Salonia A, Gallina A et al. Radical prostatectomy for incidental (stage T1a-T1b) prostate cancer: analysis of predictors for residual disease and biochemical recurrence. Eur Urol 2008; 54: 118–125.
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Pepe, P., Fraggetta, F., Galia, A. et al. Prostate cancer detection by TURP after repeated negative saturation biopsy in patients with persistent suspicion of cancer: a case–control study on 75 consecutive patients. Prostate Cancer Prostatic Dis 13, 83–86 (2010). https://doi.org/10.1038/pcan.2009.46
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DOI: https://doi.org/10.1038/pcan.2009.46
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