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Neuro-oncology

Unmasking the multiforme in glioblastoma

Nature Reviews Neurology volume 6, pages 304–305 (2010)Cite this article

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Classification of glioblastomas into various molecular entities is required for the successful application of targeted therapeutics and personalized cancer therapy. Analyses of gene expression, genomic mutations and DNA copy number identified four molecular subtypes among histopathologically indistinguishable glioblastomas. This classification suggests the existence of distinct paths of tumor cell origin and variation in therapeutic sensitivity.

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Authors and Affiliations

  1. Department of Neurosurgery, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, 21286, MD, USA

    C. Rory Goodwin

  2. Department of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, Inc., 707 North Broadway, Baltimore, 21205, MD, USA

    John Laterra

Authors
  1. C. Rory Goodwin
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  2. John Laterra
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Correspondence to John Laterra.

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The authors declare no competing financial interests.

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Goodwin, C., Laterra, J. Unmasking the multiforme in glioblastoma. Nat Rev Neurol 6, 304–305 (2010). https://doi.org/10.1038/nrneurol.2010.67

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