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Gatekeeper mechanisms for immature B cells

Lymphocyte maturation and survival depend on a canonical NF-κB activation pathway. BAFF, however, uses an alternative NF-κB pathway to mediate signaling in maturing B cells.

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Figure 1: Most BAFF signaling involves a nonclassical NF-κB pathway.

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Sun, XH., Kincade, P. Gatekeeper mechanisms for immature B cells. Nat Immunol 3, 898–899 (2002). https://doi.org/10.1038/ni1002-898

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