Multiple receptors alert cells to microbial invasion by initiating intracellular signals that modify gene expression. New work provides a more complex view of microbe-induced signaling through the adaptor CARD9.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression
Signal Transduction and Targeted Therapy Open Access 13 October 2023
-
Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk
Scientific Reports Open Access 28 June 2021
-
Molecular and physiological roles of the adaptor protein CARD9 in immunity
Cell Death & Disease Open Access 19 January 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hara, H. et al. Nat. Immunol. 8, 619–629 (2007).
Kawai, T. & Akira, S. Semin. Immunol. 19, 24–32 (2007).
Brown, G.D. Nat. Rev. Immunol. 6, 33–43 (2006).
Taylor, P.R. et al. Annu. Rev. Immunol. 23, 901–944 (2005).
Meylan, E., Tschopp, J. & Karin, M. Nature 442, 39–44 (2006).
Gantner, B.N., Simmons, R.M., Canavera, S.J., Akira, S. & Underhill, D.M. J. Exp. Med. 197, 1107–1117 (2003).
Goodridge, H.S., Simmons, R.M. & Underhill, D.M. J. Immunol. 178, 3107–3115 (2007).
Dillon, S. et al. J. Clin. Invest. 116, 916–928 (2006).
Humphrey, M.B., Lanier, L.L. & Nakamura, M.C. Immunol. Rev. 208, 50–65 (2005).
Bertin, J. et al. J. Biol. Chem. 275, 41082–41086 (2000).
Rawlings, D.J., Sommer, K. & Moreno-Garcia, M.E. Nat. Rev. Immunol. 6, 799–812 (2006).
Gross, O. et al. Nature 442, 651–656 (2006).
Hsu, Y.M. et al. Nat. Immunol. 8, 198–205 (2007).
LeibundGut-Landmann, S. et al. Nat. Immunol. 8, 630–638 (2007).
Acosta-Rodriguez, E.V. et al. Nat. Immunol. 8, 639–646 (2007).
Rogers, N.C. et al. Immunity 22, 507–517 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Colonna, M. All roads lead to CARD9. Nat Immunol 8, 554–555 (2007). https://doi.org/10.1038/ni0607-554
Issue Date:
DOI: https://doi.org/10.1038/ni0607-554
This article is cited by
-
Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression
Signal Transduction and Targeted Therapy (2023)
-
Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk
Scientific Reports (2021)
-
Molecular and physiological roles of the adaptor protein CARD9 in immunity
Cell Death & Disease (2018)
-
Proteomic study of benign and malignant pleural effusion
Journal of Cancer Research and Clinical Oncology (2016)
-
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
Nature Immunology (2010)
