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Reply to “Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis”

Nature Genetics volume 42, pages 470–471 (2010)Cite this article

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Hintzen et al. reply:

We share the authors' surprise that in a large dataset from several countries, they failed to reproduce the association between variation at the KIF1B locus and multiple sclerosis (MS) that we observed1. A role for KIF1B (kinesin family member 1B) in MS is biologically plausible given both the increasingly recognized role of kinesins in neurological disease and the recent report on Kif1b and myelination2. Our original observation has been replicated in a study of Canadian multiplex MS families3, which showed an odds ratio (OR) of 1.65 for association between rs10492972[C] and MS (G.E., unpublished data; see Supplementary Note). The recent large study by the International Multiple Sclerosis Genetics Consortium (IMSGC) demonstrated evidence for an association with KIF21B4, which encodes a molecule that shares properties with KIF1B. A recent Australian–New Zealand screen found marginal association with an area around KIF1A5.

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References

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Authors and Affiliations

  1. Department of Neurology, Erasmus MC, Rotterdam, The Netherlands

    Rogier Q Hintzen

  2. Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

    Yurii S Aulchenko & Cornelia M van Duijn

  3. Department of Clinical Neurology and The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Sriram Ramagopalan & George Ebers

Authors
  1. Rogier Q Hintzen
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  2. Yurii S Aulchenko
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  3. Sriram Ramagopalan
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  4. George Ebers
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  5. Cornelia M van Duijn
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Corresponding author

Correspondence to Rogier Q Hintzen.

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Hintzen, R., Aulchenko, Y., Ramagopalan, S. et al. Reply to “Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis”. Nat Genet 42, 470–471 (2010). https://doi.org/10.1038/ng0610-470

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