Using RNA interference to shut down harmful genes can have fatal flaw.
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References
GrimmD., et al. Nature, 441. 537 - 541 (2006).
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RobbinsM. A., et al. Nature Biotechnology, 24. 566 - 571 (2006).
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Check, E. RNA treatment kills mice. Nature (2006). https://doi.org/10.1038/news060522-10
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DOI: https://doi.org/10.1038/news060522-10