Time-resolved fluorescence resonance energy transfer (TR-FRET) measurements with selective, fluorescently labeled ligands support the existence of GPCR dimers in native tissues and suggest that activated GPCR dimers are asymmetric.
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References
Lohse, M.J. Curr. Opin. Pharmacol. 10, 53–58 (2010).
Pin, J.P. et al. Pharmacol. Rev. 59, 5–13 (2007).
Albizu, L. et al. Nat. Chem. Biol. 6, 587–594 (2010).
Ciruela, F., Vilardaga, J.P. & Fernandez-Duenas, V. Trends Biotechnol., doi:10.1016/j.tibtech.2010.05.002 (9 June 2010).
Rozenfeld, R. & Devi, L.A. Trends Pharmacol. Sci. 31, 124–130 (2010).
Daly, C.J. & McGrath, J.C. Pharmacol. Ther. 100, 101–118 (2003).
Albizu, L. et al. Mol. Pharmacol. 70, 1783–1791 (2006).
Vilardaga, J.P. et al. Nat. Chem. Biol. 4, 126–131 (2008).
Whorton, M.R. et al. Proc. Natl. Acad. Sci. USA 104, 7682–7687 (2007).
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Ambrosio, M., Lohse, M. GPCR dimers moving closer. Nat Chem Biol 6, 570–571 (2010). https://doi.org/10.1038/nchembio.409
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DOI: https://doi.org/10.1038/nchembio.409
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