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Cracking CRAC

Nature Cell Biology volume 12, pages 416–418 (2010)Cite this article

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CRACR2A is a newly discovered Ca2+-binding protein that regulates store-operated Ca2+ entry (SOCE). CRACR2A enhances SOCE by promoting the binding of the endoplasmic reticulum Ca2+ sensor STIM to Orai, a Ca2+ channel located in the plasma membrane. As intracellular Ca2+ levels rise, CRACR2A binds Ca2+ and triggers SOCE inactivation by dissociating from the Orai–STIM complex.

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Figure 1: Milestones in the discovery of molecular mechanisms governing SOCE.
Figure 2: CRACR2A is a novel component of the STIM1–Orai complex that controls SOCE.

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Authors and Affiliations

  1. Silvia Carrasco and Tobias Meyer are in the Department of Chemical and Systems Biology, 318 Campus Drive, Clark Center/Bio-X, W200, Stanford University, Stanford, CA 94305, USA. tobias1@stanford.edu,

    Silvia Carrasco & Tobias Meyer

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  1. Silvia Carrasco
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  2. Tobias Meyer
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The authors declare no competing financial interests.

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Carrasco, S., Meyer, T. Cracking CRAC. Nat Cell Biol 12, 416–418 (2010). https://doi.org/10.1038/ncb0510-416

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