Early endosomes are the first sorting station from which endocytosed materials are targeted to various intracellular destinations. Recent work has identified the FYVE-domain protein rabenosyn-5 as a bifunctional effector of the GTPases rab5 and rab4, physically connecting entry and recycling sites on early endosomes.
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Deneka, M., van der Sluijs, P. 'Rab'ing up endosomal membrane transport. Nat Cell Biol 4, E33–E35 (2002). https://doi.org/10.1038/ncb0202-e33
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DOI: https://doi.org/10.1038/ncb0202-e33
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