Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.
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van Riggelen, J., Felsher, D. Myc and a Cdk2 senescence switch. Nat Cell Biol 12, 7–9 (2010). https://doi.org/10.1038/ncb0110-7
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DOI: https://doi.org/10.1038/ncb0110-7
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