Abstract
With the increased presence of nanomaterials in commercial products, a growing public debate is emerging on whether the environmental and social costs of nanotechnology outweigh its many benefits. To date, few studies have investigated the toxicological and environmental effects of direct and indirect exposure to nanomaterials and no clear guidelines exist to quantify these effects.
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References
Matsunaga, T. & Sakaguchi, T. Molecular mechanism of magnet formation in bacteria. J. Biosci. Bioeng. 90, 1–13 (2000).
Matsunaga, T. Production of luciferase-magnetic particle complex by recombinant Magnetospirillum sp. AMB-1. Biotechnol. Bioeng. 70, 704–709 (2000).
Okamura, Y., Takeyama, H. & Matsunga, T. Two-dimensional analysis of proteins specific to the bacterial magnetic particle membrane from Magnetospirillum sp. AMB-1. Appl. Biochem. Biotech. 84–86, 441–446 (2000).
Kan, A.T. & Tomson, M.B. Ground water transport of hydrophobic organic compounds in the presence of dissolved organic matter. Environ. Toxicol. Chem. 9, 253–263 (1990).
Kersting, A.B. et al. Migration of plutonium in ground water at the Nevada Test Site. Nature 397, 56–59 (1999).
Arnall, A.H. Future Technologies, Today's Choices (Greenpeace Environmental Trust, London, 2003).
ETC Group Report. No small matter II: the case for a global moratorium (ETC Group, Ottawa, Canada, 2003).
Lesher, Sara. Will nanotech control us, or can it be controlled? The Hill, http://www.thehill.com/, 7 May 2003.
Liddle, R. Committee meets to investigate nanoscience. The Guardian, London, July 30, 2003.
Prince sparks row over nanotechnology (Commentary). The Guardian, London, April 28, 2003.
Tremblay, J.F. Fullerenes by the ton. Chem. Eng. News 81, 13–14 (2003).
Tremblay, J.F. Mitsubishi chemical aims at breakthrough. Chem. Eng. News 80, 16–17 (2002).
Borm, P.J.A. Particle toxicology: from coal mining to nanotechnology. Inhalation Toxicol. 14, 311–324 (2002).
Castranova, V. From coal mine dust to quartz: mechanisms of pulmonary pathogenicity. Inhalation Toxicol. 12, 7–14 (2000).
Courrier, H.M., Butz, N. & Vandamme, T.F. Pulmonary drug delivery systems: recent developments and prospects. Critical Rev. Ther. Drug Carrier Syst. 19, 425–498 (2002).
Chew, N.Y.K. & Chan, H.K. The role of particle properties in pharmaceutical powder inhalation formulations. J. Aerosol Med.-Deposition Clearance Effects Lung 15, 325–330 (2002).
Kawashima, Y., Serigano, T., Hino, T., Yamamoto, H. & Takeuchi, H. A new powder design method to improve inhalation efficiency of pranlukast hydrate dry powder aerosols by surface modification with hydroxypropylmethylcellulose phthalate nanospheres. Pharm. Res. 15, 1748–1752 (1998).
Edwards, M.F. & Instone, T. Particulate products—their manufacture and use. Powder Technol. 119, 9–13 (2001).
Shefer, S. & Shefer, A. Controlled release systems for skin care applications. J. Cosmet. Sci. 52, 350–353 (2001).
Spiertz, C. & Korstanje, C. A method for assessing the tactile properties of dermatological cream bases. J. Dermatol. Treatment 6, 155–157 (1995).
Federal Register. Sunscreen drug products for over-the-counter human use; final monograph. 64, no. 98, 27,666 (US Government Printing Office, Washington, DC, 1999).
Lademann, J. et al. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Appl. Skin Physiol. 12, 247–256 (1999).
Schulz, J. et al. Distribution of sunscreens on skin. Advanced Drug Del. Rev. 54, S157–S163 (2002).
Bahnemann, D.W., Kholuiskaya, S.N., Dillert, R., Kulak, A.I. & Kokorin, A.I. Photodestruction of dichloroacetic acid catalyzed by nano-sized TiO2 particles. Appl. Catalysis B-Environmental 36, 161–169 (2002).
Malato, S., Blanco, J., Vidal, A. & Richter, C. Photocatalysis with solar energy at a pilot-plant scale: an overview. Appl. Catalysis B-Environ. 37, 1–15 (2002).
Ricci, A., Chretien, M.N., Maretti, L. & Scaiano, J.C. TiO2-promoted mineralization of organic sunscreens in water suspension and sodium dodecyl sulfate micelles. Photochem. Photobiol. Sci. 2, 487–492 (2003).
Picatonotto, T., Vione, D., Carlotti, M.E. & Gallarate, M. Photocatalytic activity of inorganic sunscreens. J. Dispersion Sci. Technol. 22, 381–386 (2001).
Rossatto, V., Picatonotto, T., Vione, D. & Carlotti, M.E. Behavior of some rheological modifiers used in cosmetics under photocatalytic conditions. J. Dispersion Sci. Technol. 24, 259–271 (2003).
Hidaka, H., Horikoshi, S., Serpone, N. & Knowland, J. In vitro photochemical damage to DNA, RNA and their bases by an inorganic sunscreen agent on exposure to UVA and UVB radiation. J. Photochem. Photobiol. A-Chem. 111, 205–213 (1997).
Dunford, R. et al. Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients. FEBS Lett. 418, 87–90 (1997).
Wiesner, M., Characklis, G. & Brejchova, D. Metals in Surface Waters (eds., Allen, H., Garrison, A., & Luther, G.L. (Ann Arbor Press, Ann Arbor, MI, 1998).
U.S. House Committee on Science. Hearing on Societal Implications of Nanotechnology, April 9, 2003. 108th Congress (House Committee on Science, Washington, DC, 2003).
McHedlov-Petrossyan, N.O., Klochkov, V.K. & Andrievsky, G.V. Colloidal dispersions of fullerene C-60 in water: some properties and regularities of coagulation by electrolytes. J. Chem. Soc.-Faraday Trans. 93, 4343–4346 (1997).
Andrievsky, G.V., Klochkov, V.K., Bordyuh, A.B. & Dovbeshko, G.I. Comparative analysis of two aqueous-colloidal solutions of C-60 fullerene with help of FTIR reflectance and UV-Vis spectroscopy. Chem. Phys. Lett. 364, 8–17 (2002).
Alargova, R.G., Deguchi, S. & Tsujii, K. Stable colloidal dispersions of fullerenes in polar organic solvents. J. Am. Chem. Soc. 123, 10460–10467 (2001).
Deguchi, S., Alargova, R.G. & Tsujii, K. Stable dispersions of fullerenes, C-60 and C-70, in water. Preparation and characterization. Langmuir 17, 6013–6017 (2001).
Henry, C. Quantum dot advances—Studies show that nanoparticles have potential biological applications. Chem. Eng. News 81, 10 (2003).
McMurry, P.H. & Woo, K.S. Size distributions of 3-100-nm urban Atlanta aerosols: Measurement and observations. J. Aerosol Med.-Deposition Clearance Effects Lung 15, 169–178 (2002).
Nemmar, A. et al. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Resp. Critical Care Med. 164, 1665–1668 (2001).
Smith, S., Cheng, U.S. & Yeh, H.C. Deposition of ultrafine particles in human tracheobronchial airways of adults and children. Aerosol Sci. Technol. 35, 697–709 (2001).
Dockery, D.W. et al. An association between air-pollution and mortality in 6 United States cities. N. Engl. J. Med. 329, 1753–1759 (1993).
Wichmann, H.E. et al. Daily mortality and fine and ultrafine particles in Frankfurt Germany. Part I: Role of particle number and particle mass, vol. 98 (HEI, Cambridge, MA, 2000).
Ferin, J., Oberdorster, G., Soderholm, S.C. & Gelein, R. Pulmonary tissue access of ultrafine particles. J. Aerosol Med.-Dep. Clearance Effects Lung 4, 57–68 (1991).
Donaldson, K., Stone, V., Gilmour, P.S., Brown, D.M. & MacNee, W.N.E. Ultrafine particles: mechanisms of lung injury. Phil. Trans. R. Soc. Lond. Ser. A. Math. Phys. Eng. Sci. 358, 2741–2748 (2000).
Oberdorster, G. Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup. Environ. Health 74, 1–8 (2001).
Murphy, S.A.M., BeruBe, K.A. & Richards, R.J. Bioreactivity of carbon black and diesel exhaust particles to primary Clara and type II epithelial cell cultures. Occup. Environ. Med. 56, 813–819 (1999).
Kleeman, M.J., Schauer, J.J. & Cass, G.R. Size and composition distribution of fine particulate matter emitted from motor vehicles. Environ. Sci. Technol. 34, 1132–1142 (2000).
Yang, A. In vitro cytotoxicity testing with fluorescence-based assays in cultured human lung and dermal cells. Cell Biol. Toxicol. 18, 97–108 (2002).
Warheit, D.B. & Hartsky, M.A.N.E. Initiating the risk assessment process for inhaled particulate materials—development of short term inhalation bioassays. J. Exposure Anal. Environ. Epidemiol. 7, 313–325 (1997).
Warheit, D.B., McHugh, T.A. & Hartsky, M.A. Differential pulmonary responses in rats inhaling crystalline, colloidal or amorphous silica dusts. Scand. J. Work Environ. Health 21, 19–21 (1995).
Bolton, J.D. Problems with wear in artificial orthopaedic joint replacements: a review. Advanced Materials Forum I. Key Eng. Mater. 230–2, 447–454 (2002).
Ingham, E. & Fisher, J. Biological reactions to wear debris in total joint replacement. Proc. Inst. Mech. Eng. [H] 214, 21–37 (2000).
Kraft, C.N., Diedrich, O., Burian, B., Schmitt, O. & Wimmer, M.A. Microvascular response of striated muscle to metal debris—a comparative in vivo study with titanium and stainless steel. J. Bone Joint Surg. Br. 85B, 133–141 (2003).
Hirakawa, K., Bauer, T.W., Stulberg, B.N., Wilde, A.H. & Borden, L.S. Characterization of debris adjacent to failed knee implants of 3 different designs. Clin. Orthop. 331, 151–158 (1996).
Benz, E.B. et al. Transmission electron microscopy of intracellular particles of polyethylene from joint replacement prostheses: size distribution and cellular response. Biomaterials 22, 2835–2842 (2001).
Miyaguchi, M. et al. Human monocyte response to retrieved polymethylmethacrylate particles. J. Biomed. Mater. Res. 62, 331–337 (2002).
Lee, J.M. et al. Size of metallic and polyethylene debris particles in failed cemented total hip replacements. J. Bone Joint Surg. Br. 74, 380–384 (1992).
Sabokbar, A., Pandey, R. & Athanasou, N.A. The effect of particle size and electrical charge on macrophage-osteoclast differentiation and bone resorption. J. Mater. Sci. Mater. Med. 14, 731–738 (2003).
DeHeer, D.H., Engels, J.A., DeVries, A.S., Knapp, R.H. & Beebe, J.D. In situ complement activation by polyethylene wear debris. J. Biomed. Mater. Res. 54, 12–19 (2001).
Wooley, P.H., Nasser, S. & Fitzgerald, R.H. The immune response to implant materials in humans. Clinical Orthop. 326, 63–70 (1996).
Olivier, V., Duval, J.L., Hindie, M., Pouletaut, P. & Nagel, M.D. Comparative particle-induced cytotoxicity toward macrophages and fibroblasts. Cell Biol. Toxicol. 19, 145–159 (2003).
Boynton, E.L. et al. The effect of polyethylene particle chemistry on human monocyte–macrophage function in vitro. J. Biomed. Mater. Res. 52, 239–245 (2000).
Visuri, T. & Koskenvuo, M. Cancer risk after Mckee-Farrar total hip-replacement. Orthopedics 14, 137–142 (1991).
Wang, I.C. et al. C-60 and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation. J. Med. Chem. 42, 4614–4620 (1999).
Monti, D. et al. C60 carboxyfullerene exerts a protective activity against oxidative stress-induced apoptosis in human peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 277, 711–717 (2000).
Foley, S. et al. Cellular localisation of a water-soluble fullerene derivative. Biochem. Biophys. Res. Commun. 294, 116–119 (2002).
Bruchez, M., Moronne, M., Gin, P., Weiss, S. & Alivisatos, A. Semiconductor nanocrystals as fluorescence biological labels. Science 5383, 2013–2016 (1998).
Chan, W.C.W. & Nie, S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016–2018 (1998).
Xu, Z., Suo, Z.Y., Wei, X.W. & Zhu, D.X. Progress in research of fullerenes' biological activities. Prog. Biochem. Biophys. 25, 130–135 (1998).
Da Ros, T. & Prato, M. Medicinal chemistry with fullerenes and fullerene derivatives. Chem. Commun. 8, 663–669 (1999).
Kai, Y., Komazawa, Y., Miyajima, A., Miyata, N. & Yamakoshi, Y. 60 Fullerene as a novel photoinduced antibiotic. Fuller. Nanotub. Carbon Nanostruct. 11, 79–87 (2003).
Tsao, N., Kanakamma, P.P., Luh, T.Y., Chou, C.K. & Lei, H.Y. Inhibition of Escherichia coli-induced meningitis by carboxyfullerence. Antimicrob. Agents Chemother. 43, 2273–2277 (1999).
Nakajima, N., Nishi, C., Li, F.M. & Ikada, Y. Photo-induced cytotoxicity of water-soluble fullerene. Fullerene Sci. Technol. 4, 1–19 (1996).
Sakai, A., Yamakoshi, Y. & Miyata, N. Visible light irradiation of 60 fullerene causes killing and initiation of transformation in BALB/3T3 cells. Fullerene Sci. Technol. 7, 743–756 (1999).
Yang, X.L., Fan, C.H. & Zhu, H.S. Photo-induced cytotoxicity of malonic acid C-60 fullerene derivatives and its mechanism. Toxicol. In Vitro 16, 41–46 (2002).
Moriguchi, T., Yano, K., Hokari, S. & Sonoda, M. Effect of repeated application of C-60 combined with UVA radiation onto hairless mouse back skin. Fullerene Sci. Technol. 7, 195–209 (1999).
Rajagopalan, P., Wudl, F., Schinazi, R.F. & Boudinot, F.D. Pharmacokinetics of a water-soluble fullerene in rats. Antimicrob. Agents Chemother. 40, 2262–2265 (1996).
Tsuchiya, T., Oguri, I., Yamakoshi, Y.N. & Miyata, N. Novel harmful effects of 60 fullerene on mouse embryos in vitro and in vivo. FEBS Lett. 393, 139–145 (1996).
Ueng, T.H., Kang, J.J., Wang, H.W., Cheng, Y.W. & Chiang, L.Y. Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C-60. Toxicol. Lett. 93, 29–37 (1997).
Chen, H.H.C. et al. Renal effects of water-soluble polyarylsulfonated C-60 in rats with an acute toxicity study. Fullerene Sci. Technol. 5, 1387–1396 (1997).
Chen, H.H.C. et al. Acute and subacute toxicity study of water-soluble polyalkylsulfonated C-60 in rats. Toxicol. Pathol. 26, 143–151 (1998).
Warheit, D.B. et al. Comparative pulmonary toxicity assessment of single walled carbon nanotubes in rats. Toxicol. Sci., in the press (2003).
Lam, C. The pulmonary toxicology of single-walled carbon nanotubes. Toxicol. Sci., in the press (2003).
Carter, L.C., Carter, J.M., Nickerson, P.A., Wright, J.R. & Baier, R.E. Particle-induced phagocytic cell responses are material dependent: Foreign body giant cells vs. osteoclasts from a chick chorioallantoic membrane particle-implantation model. J. Adhesion 74, 53–77 (2000).
Dagani, R. Nanomaterials: Safe or unsafe? Chem. Eng. News 81, 30–33 (2003).
Cusan, C. et al. A new multi-charged C-60 derivative: synthesis and biological properties. Eur. J. Org. Chem. 17, 2928–2934 (2002).
Acknowledgements
The author would like to acknowledge the useful editing and input from Kristen Kulinowski, Dave Warheit, John Bucher and Kevin Ausman and to thank students John Fortner, Christie Sayes, Delia Lyons, Xuekun Chen and Cafer Tevuyz, who provided experimental data for the discussion and figures. Mark Wiesner, Joe Hughes, Mason Tomson and Jennifer West are collaborators on ongoing experiments that informed this work. Finally, the author would like to thank the National Center for Electron Microscopy at LBL for access to their high resolution TEM facilities. This work was supported by grants from the National Science Foundation (no. EEC-0118007) and the Robert A. Welch foundation (no.C-1342).
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Colvin, V. The potential environmental impact of engineered nanomaterials. Nat Biotechnol 21, 1166–1170 (2003). https://doi.org/10.1038/nbt875
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DOI: https://doi.org/10.1038/nbt875
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