Department of Neurology New York Presbyterian Hospital
Cornell University, 525 East 68th Street
New York City, New York 10021, USA
fbeal@mail.med.cornell.edu
Neuronal nitric oxide synthase (nNOS) is known to be involved in the dopaminergic
neurodegeneration that occurs in the MPTP model of Parkinson disease. Recent
studies indicate that different isoforms of NOS may act synergistically to
cause neuronal injury in Parkinson disease and other neurodegenerative diseases
(1403−1409).
