Abstract
THE repertoire of mature class II-restricted T cells is generated through a complex process of selection whereby early T cells confront class II molecules in the thymus, especially on epithelial cells1–3. Expression of class II molecules on such cells is prominent both in the cortex and in the medulla4,5. We have identified a novel class II molecule, H–2O, which is expressed only in epithelial cells of the thymic medulla and in B cells. The unusual tissue distribution and the nonpolymorphic nature of H–2O suggest that its function is different from that of classical class II molecules.
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References
Sprent, J. & Webb, S. R. Adv. Immun. 41, 39–133 (1987).
von Boehmer, H. & Kisielow, P. Science 248, 1369–1373 (1990).
Blackman, M., Kappler, J. & Marrack, P. M. Science 248, 1335–1341 (1990).
Rouse, R. V., van Ewijk, W., Jones, P. P. & Weissman, I. L. J. Immun. 122, 2508–2515 (1979).
Sprent, J., Lo, D., Er-Kay, G. & Ron, Y. Immunol. Rev. 101, 173–190 (1988).
Larhammar, D., Hammerling, U., Rask, L. & Peterson, P. A. J. biol. Chem. 260, 14111–14119 (1985).
Wake, C. T. & Flavell, R. A. Cell 42, 623–628 (1985).
Servenius, B., Rask, L. & Peterson, P. A. J. biol. Chem. 262, 8759–8766 (1987).
Vu, T. H., Tacchini-Cottier, F. M. & Jones, P. P. J. Immun. 142, 2936–2942 (1989).
Begtovich, A. B., Vu, T. H. & Jones, P. P. J. Immun. 144, 1957–1964 (1990).
Spencer, J. S. & Kubo, R. T. J. exp. Med. 169, 625–640 (1989).
Watson, A. J., DeMars, R., Trowbridge, I. S. & Bach, F. H. Nature 304, 358–361 (1983).
Cowan, E. P., Cummings, R. D., Lee, D. R., Schwartz, B. D. & Cullen, S. E. Molec. Immun. 22, 135–143 (1985).
Brown, J. H. et al. Nature 332, 845–850 (1988).
Hirokawa, K., Utsuyama, M., Morrazumi, F. & Handa, S. Thymus 8, 349–360 (1986).
Tonellle, C., DeMars, R., Long, E. O. EMBO J. 4, 2839–2847 (1985).
Rappolee, D. A., Mark, D., Banda, M. J. & Werb, Z. Science 241, 708–712 (1988).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Jones, P. P. in Selected Methods in Cellular Immunology (eds Mishell, B. P. & Shigii, S. P.) 398–440 (Freeman, San Francisco, 1980).
Lawrence, S. K. et al. Cell 58, 583–594 (1989).
Hubbard, A. L. & Cohn, Z. I. J. Cell Biol. 64, 438–460 (1975).
Symington, F. W. & Sprent, J. J. Immun. 14, 53–61 (1981).
Ron, Y. & Sprent, J. J. Immun. 138, 2848–2856 (1987).
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Karlsson, L., Surh, C., Sprent, J. et al. A novel class II MHC molecule with unusual tissue distribution. Nature 351, 485–488 (1991). https://doi.org/10.1038/351485a0
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DOI: https://doi.org/10.1038/351485a0
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