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This cover portrays a flowing river, symbolizing the aging of a mother, surrounded by jujube and lotus plants. The seeds of these plants, standing as symbols of having many children, are traditionally given as gifts to newlyweds in Chinese culture to bestow blessings of fertility. Within the river, there are mitochondria undergoing shifts from tubular to donut-shaped structures as the mother ages. These mitochondria, inherited by the offspring, have enduring impacts on their trait formations. See page 821–834 by Runshuai Zhang et al. for details.