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Treatment with mesenchymal stem cells (MSCs) can improve the outcomes of COVID-19 patients by restoring a harmonious homeostasis of the immune microenvironment disrupted by SARS-CoV-2 attack and promoting the immune system recovery. This process suggests a new interpretation to the story of “Moses divided the Red Sea” in the Exodus of the Bible: MSC therapy represents a promising new way in the treatment of COVID-19. See page 1244-1262 by Rongjia Zhu et al. for details.