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The main inhibitory neurotransmitter in the brain, GABA, influences neuronal and glial activity in a prolonged manner via GABAB receptor, a prototypical class C GPCR. GABAB receptor is an obligatory heterodimer of two subunits. They perform a complicated “pas de deux” to transduce the extracellular stimuli into cells. See page 564-573 by Chunyou Mao et al. for details.