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Anticancer therapeutics aimed at the inhibition of mTORC1 activity shift metabolism to favor the degradation of extracellular proteins. Recently Thompson and colleagues demonstrated a novel regulatory mechanism whereby mTORC1 plays a distinct role as a key regulator of metabolism depending on the environmental nutrient status.
Cytosines in genomic DNA come in different flavors. A recent paper published in Nature reveals that an oxidized variety, 5-carboxylcytosine, is recognized by the elongating RNA polymerase, shedding light on the role of DNA oxidation in transcription regulation.
Two proteolytic enzymes, β- and γ-secretases, work together to produce the amyloid β-peptide of Alzheimer's disease. New evidence suggests that these proteases directly interact and compounds that disrupt this interaction reduce amyloid β-peptide levels without directly blocking either enzyme's solo activity.
