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Tim Koopmans and Yuval Rinkevich review recent findings linking the mesothelium’s embryonic programs that drive epithelial-to-mesenchyme transition with adult pathologies, such as fibrosis, acute scarring, and cancer metastasis. They highlight new avenues for drug development that would target pathways of the mesothelium’s mesenchymal transition.
In honeybees, genotypically identical females develop into queens or sterile workers, depending on their diets. In this review, Ryszard Maleszka discusses the controversial role of the royal jelly protein Royalactin in caste determination and provides a framework for moving beyond the master inducer concept.