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Invasive and non-invasive neuromodulation in movement disorders

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Invasive neuromodulation therapies in movement disorders that target specific brain regions have paved the way for modulation of specific underlying networks. Deep Brain Stimulation (DBS) is a well-established therapy for movement disorders - namely Parkinson disease, tremor, and dystonia - whereas non-invasive stimulation such as focused ultrasound stimulation (FUS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (TDCS) are in experimental or preclinical stages. 

There is consensus that movement disorders are caused by dysfunction of neuronal circuits, which makes this a key target for patient treatment. At present, treating these disorders is primarily focused on phenotypes specific to Parkinson’s disease (i.e. motor symptoms, for example: dyskinesia, akinesia, tremor etc). However, non-motor symptoms also jeopardize the quality of life for individuals with these disorders, and should also be considered in treatment options. Treating the entire network dysfunction may therefore represent the best strategy to overcome both motor and non-motor symptoms. 

This Collection will showcase developments in invasive and non-invasive neuromodulation therapies that will advance the field towards this aim for holistic treatment. We particularly welcome submissions on topics such as: 

  • Developments in established invasive neuromodulation therapies (For ex: deep brain stimulation) for treating movement disorders patients specially Parkinson’s disease, tremor and dystonia.
  • Experimental and preclinical non-invasive stimulation therapies (FUS, TMS, TDCS, TACS) for treating movement disorders patients specially Parkinson’s disease, tremor, and dystonia.
  • Emerging neuromodulation (e.g. opto- or pharmaco- genetics, ultrasonic and neurofeedback) technologies and future perspective for treating movement disorders.
  • Electrophysiological approaches that foster and improve neuromodulation therapies.
  • Advanced multimodal neuroimaging techniques to derive underlying neuronal networks involved in movement disorders. 
  •  Translational approaches for improving invasive neuromodulation therapies for movement disorders.
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Dementia and Alzheimer's disease medical concept, 3D illustration. Memory loss, brain aging. Conceptual image showing blurred brain with loss of neuronal networks

Editors

  • Muthuraman Muthuraman, PhD  &

    Muthuraman Muthuraman, PhD

    Neural Engineering with Signal Analytics and Artificial Intelligence (NESA-AI), Universitätsklinikum Würzburg Department of Neurology, Würzburg, Germany

  • Aparna Wagle Shukla, MD

    Aparna Wagle Shukla, MD

    Norman Fixel Institute for Neurological Diseases, University of Florida, FL, USA

Dr Muthuraman’s research interests focus on movement disorder patients using computational methods for time series analysis and source analysis on oscillatory signals, function of oscillatory activity in central motor systems, biomedical statistics, connectivity analyses, multimodal signal processing and analyses of EEG, MEG, fMRI and EMG, structural and network analyses on anatomical MRI and DTI, machine learning and deep learning.

 

 

Dr. Wagle Shukla is a Professor of Neurology at the University of Florida. She is the Director for Clinical trials and Division Chief for Movement Disorders Research at the Norman Fixel Institute for Neurological Diseases. Her primary focus is advancing clinical research for Parkinson’s disease, dystonia, and tremor with neuromodulation-based interventions such as transcranial magnetic stimulation and deep brain stimulation.