Collection 09 January 2020

25 Years of Gene Therapy

January 2020 marks the 25^th Anniversary of Gene Therapy. To highlight this journal’s contributions over the last 25 years we have created an online collection of 25 papers: those most cited each year between 1997-2019, our most cited review ever and, as Editor’s Choice, a seminal paper describing AAV purification methods which is our top-four of all time. The collection features many major technologies: nonviral, AAV, adenoviral, retroviral and HSV vectors, microRNA, RNAi and genome editing, and the clinical trial of Glybera. We hope our readers will enjoy it. We raise a toast to the next 25 Years!

Content

HIV infection alters the human epigenetic landscape
- Lei Chen
- Shiqi Zhang
- Yu-Dong Cai
Article15 Nov 2018 Gene Therapy
AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy
- Hengchao Chen
- Yazhi Xing
- Jian Wang
ArticleOpen Access13 Mar 2018 Gene Therapy
Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy
- E Ilett
- T Kottke
- R Vile
Original Article25 Oct 2016 Gene Therapy
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
- R Kaminski
- R Bella
- K Khalili
Short Communication19 May 2016 Gene Therapy
Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus
- S Zhen
- L Hua
- X Gao
Original Article5 Feb 2015 Gene Therapy
MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain
- L Zeng
- X He
- G-Y Yang
Original Article24 Oct 2013 Gene Therapy
Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPL^S447X) gene therapy for lipoprotein lipase deficiency: an open-label trial
- D Gaudet
- J Méthot
- S van Deventer
Original Article21 Jun 2012 Gene Therapy
AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
- T Kiyota
- K L Ingraham
- T Ikezu
Original Article15 Sep 2011 Gene Therapy
Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution
- K-M R Prasad
- Y Xu
- B A French
Original Article12 Aug 2010 Gene Therapy
High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency
- E Ayuso
- F Mingozzi
- J F Wright
Original Article3 Dec 2009 Gene Therapy
Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV
- S R Singh
- H E Grossniklaus
- U B Kompella
Original Article5 Feb 2009 Gene Therapy
The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer
- E Wisse
- F Jacobs
- B De Geest
Original Article10 Apr 2008 Gene Therapy
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
- H Hatakeyama
- H Akita
- H Harashima
Original Article17 Aug 2006 Gene Therapy
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
- A Santel
- M Aleku
- J Kaufmann
Original Article20 Apr 2006 Gene Therapy
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
- B Urban-Klein
- S Werth
- A Aigner
Brief Communication23 Dec 2004 Gene Therapy
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model
- K Nakamura
- Y Ito
- H Hamada
Research Article13 May 2004 Gene Therapy
ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties
- B L Liu
- M Robinson
- R S Coffin
Research Article10 Feb 2003 Gene Therapy
Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo
- F Scherer
- M Anton
- C Plank
Research Article22 Feb 2002 Gene Therapy
Gene Therapy Progress and Prospects: Nonviral vectors
- T Niidome
- L Huang
Review29 Nov 2002 Gene Therapy
Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis
- DM McCarty
- PE Monahan
- RJ Samulski
Research Article15 Aug 2001 Gene Therapy
Plat-E: an efficient and stable system for transient packaging of retroviruses
- S Morita
- T Kojima
- T Kitamura
Viral Transfer Technology14 Jun 2000 Gene Therapy
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
- F Liu
- Y K Song
- D Liu
Paper9 Aug 1999 Gene Therapy
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
- S Zolotukhin
- B J Byrne
- N Muzyczka
Paper25 Jun 1999 Gene Therapy
The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells
- M Ogris
- P Steinlein
- E Wagner
Paper14 Oct 1998 Gene Therapy
The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes
- MX Tang
- FC Szoka
Paper1 Aug 1997 Gene Therapy

25 Years of Gene Therapy

Content

HIV infection alters the human epigenetic landscape

AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy

Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus

MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain

Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPL^S447X) gene therapy for lipoprotein lipase deficiency: an open-label trial

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model

ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo

Gene Therapy Progress and Prospects: Nonviral vectors

Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

Plat-E: an efficient and stable system for transient packaging of retroviruses

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells

The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes

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