Special Issue on Caspases
Caspases are cysteine proteases that are essential for executing apoptosis. In recent years it has become clear that in addition to their role in apoptosis, many caspases have pleiotropic functions. This review series includes comprehensive articles by experts in the caspase field, and covers the basic biology of caspases, their mechanisms of activation, cellular substrates, natural and synthetic inhibitors, apoptopic and non-apoptopic functions and role in inflammation and immunity. This compendium of up-to-date articles should serve as a key resource to researchers in biochemistry/enzymology, cell biology, immunology, virology and drug discovery.
See articles marked 
TABLE OF CONTENTS
Volume 14, Issue 1 (January 2007)
Editorial
Caspases and their many biological functions
FREE
S Kumar
Cell Death Differ 14: 1-2; advance online publication, November 3, 2006; doi:10.1038/sj.cdd.4402064
News and Commentary
p53 downstream target genes and tumor suppression: a classical view in evolution FREE
L M Rozan and W S El-Deiry
Cell Death Differ 14: 3-9; advance online publication, October 27, 2006; doi:10.1038/sj.cdd.4402058
Reviews
Inflammatory caspases and inflammasomes: master switches of inflammation
FREE
F Martinon and J Tschopp
Cell Death Differ 14: 10-22; advance online publication, September 15, 2006; doi:10.1038/sj.cdd.4402038
The inflammatory caspases: guardians against infections and sepsis
FREE
A M Scott and M Saleh
Cell Death Differ 14: 23-31; advance online publication, September 15, 2006; doi:10.1038/sj.cdd.4402026
Caspase function in programmed cell death
FREE
S Kumar
Cell Death Differ 14: 32-43; advance online publication, November 3, 2006; doi:10.1038/sj.cdd.4402060
Caspases in cell survival, proliferation and differentiation
FREE
M Lamkanfi, N Festjens, W Declercq, T Vanden Berghe and P Vandenabeele
Cell Death Differ 14: 44-55; advance online publication, October 20, 2006; doi:10.1038/sj.cdd.4402047
Apoptosome: a platform for the activation of initiator caspases
FREE
Q Bao and Y Shi
Cell Death Differ 14: 56-65; advance online publication, September 15, 2006; doi:10.1038/sj.cdd.4402028
Caspase substrates
FREE
J C Timmer and G S Salvesen
Cell Death Differ 14: 66-72; advance online publication, November 3, 2006; doi:10.1038/sj.cdd.4402059
Caspase inhibitors: viral, cellular and chemical FREE
B A Callus and D L Vaux
Cell Death Differ 14: 73-78; advance online publication, September 8, 2006; doi:10.1038/sj.cdd.4402034
Original Papers
Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3
expression FREE
Y Xu, H-S Kim, Y Joo, Y Choi, K-A Chang, C H Park, K-Y Shin, S Kim, Y-H Cheon, T-K Baik, J-H Kim and Y-H Suh
Cell Death Differ 14: 79-91; advance online publication, April 28, 2006; doi:10.1038/sj.cdd.4401928
ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity FREE
M Srivastava, H Scherr, M Lackey, D Xu, Z Chen, J Lu and A Bergmann
Cell Death Differ 14: 92-102; advance online publication, April 28, 2006; doi:10.1038/sj.cdd.4401931
Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development FREE
H-J Kim, S-H Kim, S-O Shim, E Park, C Kim, K Kim, M A Tanouye and J Yim
Cell Death Differ 14: 103-115; advance online publication, April 21, 2006; doi:10.1038/sj.cdd.4401935
NAD+ and axon degeneration revisited: Nmnat1 cannot substitute for WldS to delay Wallerian degeneration FREE
L Conforti, G Fang, B Beirowski, M S Wang, L Sorci, S Asress, R Adalbert, A Silva, K Bridge, X P Huang, G Magni, J D Glass and M P Coleman
Cell Death Differ 14: 116-127; advance online publication, April 28, 2006; doi:10.1038/sj.cdd.4401944
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets FREE
M G Hinds, C Smits, R Fredericks-Short, J M Risk, M Bailey, D C S Huang and C L Day
Cell Death Differ 14: 128-136; advance online publication, April 28, 2006; doi:10.1038/sj.cdd.4401934
Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-
B FREE
A C Williams, H Smartt, A M H-Zadeh, M MacFarlane, C Paraskeva and T J Collard
Cell Death Differ 14: 137-145; advance online publication, April 28, 2006; doi:10.1038/sj.cdd.4401919
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy FREE
A Hamacher-Brady, N R Brady, S E Logue, M R Sayen, M Jinno, L A Kirshenbaum, R A Gottlieb and Å B Gustafsson
Cell Death Differ 14: 146-157; advance online publication, April 28, 2006; doi:10.1038/sj.cdd.4401936
Inhibition of RelA phosphorylation sensitizes apoptosis in constitutive NF-kappaB-expressing and chemoresistant cells FREE
S K Manna, P Manna and A Sarkar
Cell Death Differ 14: 158-170; advance online publication, April 28, 2006; doi:10.1038/sj.cdd.4401929
A new insight into phagocytosis of apoptotic cells: proteolytic enzymes divert the recognition and clearance of polymorphonuclear leukocytes by macrophages FREE
K Guzik, M Bzowska, J Smagur, O Krupa, M Sieprawska, J Travis and J Potempa
Cell Death Differ 14: 171-182; advance online publication, April 21, 2006; doi:10.1038/sj.cdd.4401927
Letters to the Editor
Characterization of LPS and interferon-
triggered activation-induced cell death in N9 and primary microglial cells: induction of the mitochondrial gateway by nitric oxide FREE
L Mayo and R Stein
Cell Death Differ 14: 183-186; advance online publication, June 16, 2006; doi:10.1038/sj.cdd.4401989
Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKB
FREE
S Kiessling, C Lutz-Nicoladoni, A Olsson, N Harald, G Baier and A Villunger
Cell Death Differ 14: 186-189; advance online publication, June 16, 2006; doi:10.1038/sj.cdd.4402000
DNA damage-inducing agent-elicited -secretase activity is dependent on Bax/Bcl-2 pathway but not on caspase cascades FREE
S M Jin, H J Cho, M W Jung and I Mook-Jung
Cell Death Differ 14: 189-192; advance online publication, June 30, 2006; doi:10.1038/sj.cdd.4402003
Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells FREE
C Simone and A Giordano
Cell Death Differ 14: 192-195; advance online publication, July 14, 2006; doi:10.1038/sj.cdd.4402008
Corrigenda
Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells FREE
C Simone and A Giordano
Cell Death Differ 14: 196; advance online publication, September 8, 2006; doi:10.1038/sj.cdd.4402032
Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBa FREE
S Kiessling, C Lutz-Nicoladoni, A Olsson, N Harald, G Baier and A Villunger
Cell Death Differ 14: 196; advance online publication, July 28, 2006; doi:10.1038/sj.cdd.4402021
