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Cell Procurement

Efficient mobilization of PBSC with vinorelbine/G-CSF in patients with malignant lymphoma

Bone Marrow Transplantation volume 44, pages 75–79 (2009)Cite this article

Abstract

High-dose chemotherapy (HDT) and hematopoietic SCT are effective in patients with relapsing or refractory malignant lymphoma. Collection of sufficient numbers of stem cells is a prerequisite for such a therapy. In a pilot trial, we evaluated the feasibility of stem cell mobilization with vinorelbine/G-CSF in patients with lymphoma, a regimen allowing precise timing and harvesting of sufficient stem cells in myeloma patients. Forty-five patients with lymphoma received vinorelbine 35 mg/m2 i.v. on day 1 and G-CSF 10 μg/kg/day s.c., divided in two daily doses from day 4 until collection. Stem cell collection was successfully performed in 43 patients (96%) with a median of 3.6 × 106 CD34+ cells/kg (range: 1.4–16) in the collected product. In 28 patients (62%), the first stem cell apheresis was performed on day 8, and for 28 patients a sufficient stem cell yield was reached with one apheresis only. All 43 patients underwent high-dose chemotherapy with BEAM and auto-SCT with hematological recovery on time and without unexpected toxicity. In conclusion, vinorelbine/G-CSF allows accurate timing and safe harvesting of sufficient stem cells in patients with malignant lymphoma.

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Acknowledgements

We gratefully acknowledge Mrs Hannelore Oesterreicher for excellent technical assistance.

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Authors and Affiliations

  1. Center of Oncology/Hematology and Transfusion Medicine, Kantonsspital Aarau, Aarau, Switzerland

    M Heizmann, A C O'Meara, P R Moosmann, M Zuberbühler, P Fernandez, J Burger, M Wernli & M J Bargetzi

  2. Center of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland

    I A F M Heijnen, P Fernandez & A Huber

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  1. M Heizmann
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  2. A C O'Meara
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  3. P R Moosmann
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  4. I A F M Heijnen
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  5. M Zuberbühler
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  6. P Fernandez
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  7. J Burger
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  9. M Wernli
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  10. M J Bargetzi
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Correspondence to M Heizmann.

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Heizmann, M., O'Meara, A., Moosmann, P. et al. Efficient mobilization of PBSC with vinorelbine/G-CSF in patients with malignant lymphoma. Bone Marrow Transplant 44, 75–79 (2009). https://doi.org/10.1038/bmt.2008.434

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