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Peripheral blood stem cell transplantation for POEMS syndrome

Bone Marrow Transplantation volume 30, pages 401–404 (2002)Cite this article

Abstract

In common with other plasma cell dyscrasias in which a small tumour burden is associated with severe clinical symptoms (notably systemic AL amyloidosis) the possible benefits of dose intensification are yet to be fully explored in POEMS syndrome. One important issue is whether the toxicity of the procedure is significantly increased in this group. We report two cases of POEMS syndrome with solitary asymptomatic bone lesions treated with high-dose melphalan (200 mg/m2) and peripheral blood stem cell (PBSC) rescue. In both cases there was minimal peri-transplant morbidity and a subsequent substantial and maintained improvement in the peripheral neuropathy.

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Authors and Affiliations

  1. Department of Haematology, University College London Hospitals, London, UK

    KS Peggs, PD Kottaridis & K Yong

  2. Department of Radiotherapy, University College London Hospitals, London, UK

    G Tobias

  3. Department of Neurology, University College London Hospitals, London, UK

    M Reilly

  4. Bone Marrow Transplant Unit, Queen Elizabeth Hospital, Birmingham, UK

    S Paneesha, RK Chakraverty & P Mahendra

Authors
  1. KS Peggs
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  2. S Paneesha
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  3. PD Kottaridis
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  4. RK Chakraverty
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  5. G Tobias
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  6. M Reilly
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  7. P Mahendra
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  8. K Yong
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Peggs, K., Paneesha, S., Kottaridis, P. et al. Peripheral blood stem cell transplantation for POEMS syndrome. Bone Marrow Transplant 30, 401–404 (2002). https://doi.org/10.1038/sj.bmt.1703670

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  • DOI: https://doi.org/10.1038/sj.bmt.1703670

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