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Extramedullary T cell lymphoblastic transformation of chronic myeloid leukaemia successfully treated with matched unrelated donor bone marrow transplantation

Bone Marrow Transplantation volume 26, pages 1111–1112 (2000)Cite this article

Abstract

Chronic myeloid leukaemia (CML) inevitably terminates in blast crisis (BC) which is of myeloid phenotype in approximately two-thirds and B-lymphoid in one-third of patients. T cell BC is rare and associated with poor prognosis. We describe the case of a 48-year-old woman with extramedullary T cell lymphoblastic transformation. After treatment with combination chemotherapy she achieved a second chronic phase and underwent an allogeneic BMT from an HLA-matched unrelated donor. At 30 months follow-up she is still in complete molecular remission and in good clinical condition. We conclude that unrelated donor BMT should be considered as a therapeutic option for patients with extramedullary BC. Bone Marrow Transplantation (2000) 26, 1111–1112.

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Authors and Affiliations

  1. Division of Haematology, Department of Medicine, Karl-Franzens University, Graz, Austria

    U Apfelbeck, P Neumeister, W Linkesch & H Sill

  2. Institute of Pathology, Karl-Franzens University, Graz, Austria

    G Hoefler

  3. Institute of Medical Biology, University of Vienna, Austria

    C Fonatsch

Authors
  1. U Apfelbeck
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  2. G Hoefler
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  3. P Neumeister
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  4. C Fonatsch
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  5. W Linkesch
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  6. H Sill
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Apfelbeck, U., Hoefler, G., Neumeister, P. et al. Extramedullary T cell lymphoblastic transformation of chronic myeloid leukaemia successfully treated with matched unrelated donor bone marrow transplantation. Bone Marrow Transplant 26, 1111–1112 (2000). https://doi.org/10.1038/sj.bmt.1702665

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  • DOI: https://doi.org/10.1038/sj.bmt.1702665

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