Advance Online Publication

Papers are listed below grouped by their online publication date.

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June 27 2017

Short Communication

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Daniele Oddo, Giulia Siravegna, Annunziata Gloghini, Claudio Vernieri, Benedetta Mussolin, Federica Morano, Giovanni Crisafulli, Rosa Berenato, Giorgio Corti, Chiara Costanza Volpi, Michela Buscarino, Monica Niger, Philip D Dunne, Giuseppe Rospo, Emanuele Valtorta, Alice Bartolini, Giovanni Fucà, Simona Lamba, Antonia Martinetti, Maria Di Bartolomeo, Filippo de Braud, Alberto Bardelli, Filippo Pietrantonio and Federica Di Nicolantonio

Br J Cancer advance online publication, June 27, 2017; doi:10.1038/bjc.2017.196

Full Paper

Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study

A Y Zhang, I Judson, C Benson, J S Wunder, I Ray-Coquard, R J Grimer, R Quek, E Wong, A B Miah, P C Ferguson, A Dufresne, J Y H Teh, M Stockler and M H N Tattersall

Br J Cancer advance online publication, June 27, 2017; doi:10.1038/bjc.2017.198

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June 22 2017

Editorial

Sequential versus concurrent chemotherapy for adjuvant breast cancer: does dose intensity matter?

N LeVasseur and S K Chia

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.176

Short Communication

No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy Open

Alexandra K Walker, Christiana Kartsonaki, Elena Collantes, Judith Nicholson, Duncan C Gilbert and Anne E Kiltie

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.188

Full Papers

A cancer geography paradox? Poorer cancer outcomes with longer travelling times to healthcare facilities despite prompter diagnosis and treatment: a data-linkage study

Melanie Turner, Shona Fielding, Yuhan Ong, Chris Dibben, Zhiqianq Feng, David H Brewster, Corri Black, Amanda Lee and Peter Murchie

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.180

Characterisation of blood-derived exosomal hTERT mRNA secretion in cancer patients: a potential pan-cancer marker

Hadar Goldvaser, Anna Gutkin, Einat Beery, Yonatan Edel, Jardena Nordenberg, Ofir Wolach, Ester Rabizadeh, Orit Uziel and Meir Lahav

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.166

Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies

Raghava Sharma, Xianming Huang, Rolf A Brekken and Alan J Schroit

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.183

Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331  Open

Marek Sierzega, Marcin Kaczor, Piotr Kolodziejczyk, Jan Kulig, Marek Sanak and Piotr Richter

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.190

Human equilibrative nucleoside transporter 1 gene expression is associated with gemcitabine efficacy in advanced leiomyosarcoma and angiosarcoma

Bruno Vincenzi, Silvia Stacchiotti, Paola Collini, Francesco Pantano, Carla Rabitti, Giuseppe Perrone, Michele Iuliani, Alfonso Baldi, Giuseppe Badalamenti, Roberta Sanfilippo, Daniele Santini, Andrea Onetti Muda, Alessandro Gronchi, Paolo Casali, Angelo Paolo Dei Tos and Giuseppe Tonini

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.187

Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer

Yusuke Goto, Akira Kurozumi, Takayuki Arai, Nijiro Nohata, Satoko Kojima, Atsushi Okato, Mayuko Kato, Kazuto Yamazaki, Yasuo Ishida, Yukio Naya, Tomohiko Ichikawa and Naohiko Seki

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.191

Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy Open

K J Gash, A C Chambers, D E Cotton, A C Williams and M G Thomas

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.175

Sequential vs concurrent epirubicin and docetaxel as adjuvant chemotherapy for high-risk, node-negative, early breast cancer: an interim analysis of a randomised phase III study from the Hellenic Oncology Research Group

Dimitrios Mavroudis, Emmanouil Saloustros, Ioannis Boukovinas, Pavlos Papakotoulas, Stylianos Kakolyris, Nikolaos Ziras, Charalampos Christophylakis, Nikolaos Kentepozidis, Georgios Fountzilas, Georgios Rigas, Ioannis Varthalitis, Konstantinos Kalbakis, Sofia Agelaki, Dora Hatzidaki and Vasilios Georgoulias

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.158

Letters to the Editor

Comment on 'The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis' FREE

Alain Braillon

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.184

Reply to ‘Comment on ‘The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis’’ FREE

L Zgaga, P G Vaughan-Shaw, F O’Sullivan, S M Farrington, E Theodoratou, H Campbell and M G Dunlop

Br J Cancer advance online publication, June 22, 2017; doi:10.1038/bjc.2017.185

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June 20 2017

Full Papers

CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients

Lourdes Barrera, Edgar Montes-Servín, Juan-Manuel Hernandez-Martinez, María de los Ángeles García-Vicente, Elizabeth Montes-Servín, Marytere Herrera-Martínez, José C Crispín, José Rafael Borbolla-Escoboza and Oscar Arrieta

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.173

Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer

Tsuyoshi Hata, Ichiro Takemasa, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Tsunekazu Mizushima, Yuichiro Doki and Masaki Mori

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.163

Infradiaphragmatic irradiation and high procarbazine doses increase colorectal cancer risk in Hodgkin lymphoma survivors

Anna M van Eggermond, Michael Schaapveld, Cécile PM Janus, Jan Paul de Boer, Augustinus DG Krol, Josée M Zijlstra, Richard WM van der Maazen, Leontien C Kremer, Monique E van Leerdam, Marieke WJ Louwman, Otto Visser, Marie L De Bruin, Berthe MP Aleman and Flora E van Leeuwen

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.177

MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer

P Zhang, W M Tang, H Zhang, Y Q Li, Y Peng, J Wang, G N Liu, X T Huang, J J Zhao, G Li, A M Li, Y Bai, Y Chen, Y X Ren, G X Li, Y D Wang, S D Liu and J D Wang

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.181

Oral squamous cell carcinoma patients can be differentiated from healthy individuals with label-free serum proteomics

Mayank Saraswat, Antti Mäkitie, Rahul Agarwal, Sakari Joenväärä and Suvi Renkonen

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.172

Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment

Richard Kim, E Gabriela Chiorean, Manik Amin, Caio Max S Rocha-Lima, Jitendra Gandhi, William P Harris, Tao Song and David Portnoy

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.160

Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas

Nadège Presneau, Laure Alice Duhamel, Hongtao Ye, Roberto Tirabosco, Adrienne M Flanagan and Malihe Eskandarpour

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.174

Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study

Chaya S Moskowitz, Joanne F Chou, Charles A Sklar, Dana Barnea, Cécile M Ronckers, Danielle Novetsky Friedman, Joseph P Neglia, Lucie Turcotte, Rebecca M Howell, Tara O Henderson, Gregory T Armstrong, Wendy M Leisenring, Leslie L Robison, Flora E van Leeuwen, Malcolm C Pike and Kevin C Oeffinger

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.169

The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab

Laura Demurtas, Marco Puzzoni, Riccardo Giampieri, Pina Ziranu, Valeria Pusceddu, Alessandra Mandolesi, Chiara Cremolini, Gianluca Masi, Fabio Gelsomino, Carlotta Antoniotti, Cristian Loretelli, Fausto Meriggi, Alberto Zaniboni, Alfredo Falcone, Stefano Cascinu and Mario Scartozzi

Br J Cancer advance online publication, June 20, 2017; doi:10.1038/bjc.2017.178

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June 15 2017

Full Papers

Extreme assay sensitivity in molecular diagnostics further unveils intratumour heterogeneity in metastatic colorectal cancer as well as artifactual low-frequency mutations in the KRAS gene Open

Sara Mariani, Luca Bertero, Simona Osella-Abate, Cristiana Di Bello, Paola Francia di Celle, Vittoria Coppola, Anna Sapino, Paola Cassoni and Caterina Marchiò

Br J Cancer advance online publication, June 15, 2017; doi:10.1038/bjc.2017.170

Tumour heterogeneity poses a significant challenge to cancer biomarker research Open

Karolina Cyll, Elin Ersvær, Ljiljana Vlatkovic, Manohar Pradhan, Wanja Kildal, Marte Avranden Kjær, Andreas Kleppe, Tarjei S Hveem, Birgitte Carlsen, Silje Gill, Sven Löffeler, Erik Skaaheim Haug, Håkon Wæhre, Prasanna Sooriakumaran and Håvard E Danielsen

Br J Cancer advance online publication, June 15, 2017; doi:10.1038/bjc.2017.171

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June 13 2017

Full Papers

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative

Hans R Hendriks, Anne-Sophie Govaerts, Iduna Fichtner, Sally Burtles, Andrew D Westwell and Godefridus J Peters on behalf of the EORTC-PAMM Group

Br J Cancer advance online publication, June 13, 2017; doi:10.1038/bjc.2017.167

Predicting Infectious ComplicatioNs in Children with Cancer: an external validation study

Gabrielle M Haeusler, Karin A Thursky, Francoise Mechinaud, Franz E Babl, Richard De Abreu Lourenco, Monica A Slavin and Robert Phillips

Br J Cancer advance online publication, June 13, 2017; doi:10.1038/bjc.2017.154

Prioritising action on occupational carcinogens in Europe: a socioeconomic and health impact assessment

J W Cherrie, S Hutchings, M Gorman Ng, R Mistry, C Corden, J Lamb, A Sánchez Jiménez, A Shafrir, M Sobey, M van Tongeren and L Rushton

Br J Cancer advance online publication, June 13, 2017; doi:10.1038/bjc.2017.161

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June 8 2017

Full Papers

KIF15 promotes pancreatic cancer proliferation via the MEK–ERK signalling pathway

Jie Wang, Xingjun Guo, Chencheng Xie and Jianxin Jiang

Br J Cancer advance online publication, June 8, 2017; doi:10.1038/bjc.2017.165

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies Open

Muhammad A Alvi, Maurice B Loughrey, Philip Dunne, Stephen McQuaid, Richard Turkington, Marc-Aurel Fuchs, Claire McGready, Victoria Bingham, Brendan Pang, Wendy Moore, Perry Maxwell, Mark Lawler, Jacqueline A James, Graeme I Murray, Richard H Wilson and Manuel Salto-Tellez

Br J Cancer advance online publication, June 8, 2017; doi:10.1038/bjc.2017.168

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June 6 2017

Full Papers

Impact of body mass index on ovarian cancer survival varies by stage

Elisa V Bandera, Valerie S Lee, Bo Qin, Lorna Rodriguez-Rodriguez, C Bethan Powell and Lawrence H Kushi

Br J Cancer advance online publication, June 6, 2017; doi:10.1038/bjc.2017.162

MicroRNA-199b-5p attenuates TGF-β1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

Shao-jun Zhou, Fu-yao Liu, An-hong Zhang, Hui-fang Liang, Ye Wang, Rong Ma, Yuan-hui Jiang and Nian-feng Sun

Br J Cancer advance online publication, June 6, 2017; doi:10.1038/bjc.2017.164

The influence of timing of radiation therapy following breast-conserving surgery on 10-year disease-free survival

Marissa C van Maaren, Reini W Bretveld, Jan J Jobsen, Renske K Veenstra, Catharina GM Groothuis-Oudshoorn, Hendrik Struikmans, John H Maduro, Luc JA Strobbe, Philip MP Poortmans and Sabine Siesling

Br J Cancer advance online publication, June 6, 2017; doi:10.1038/bjc.2017.159

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May 30 2017

Minireview

Akt as a target for cancer therapy: more is not always better (lessons from studies in mice) Open

Qi Wang, Xinyu Chen and Nissim Hay

Br J Cancer advance online publication, May 30, 2017; doi:10.1038/bjc.2017.153

Full Papers

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia

Maribel Forero-Castro, Cristina Robledo, Rocío Benito, Irene Bodega-Mayor, Inmaculada Rapado, María Hernández-Sánchez, María Abáigar, Jesús Maria Hernández-Sánchez, Miguel Quijada-Álamo, José María Sánchez-Pina, Mónica Sala-Valdés, Fernanda Araujo-Silva, Alexander Kohlmann, José Luis Fuster, Maryam Arefi, Natalia de las Heras, Susana Riesco, Juan N Rodríguez, Lourdes Hermosín, Jordi Ribera, Mireia Camos Guijosa, Manuel Ramírez, Cristina Díaz de Heredia Rubio, Eva Barragán, Joaquín Martínez, José M Ribera, Elena Fernández-Ruiz and Jesús-María Hernández-Rivas

Br J Cancer advance online publication, May 30, 2017; doi:10.1038/bjc.2017.152

Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer

Daniel Kazdal, Alexander Harms, Volker Endris, Roland Penzel, Mark Kriegsmann, Florian Eichhorn, Thomas Muley, Albrecht Stenzinger, Nicole Pfarr, Wilko Weichert and Arne Warth

Br J Cancer advance online publication, May 30, 2017; doi:10.1038/bjc.2017.155

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April 11 2017

Letters to the Editor

Comment on ‘Effect of population breast screening on breast cancer mortality up to 2005 in England and Wales: an individual-level cohort study’ FREE

Anthony B Miller

Br J Cancer advance online publication, April 11, 2017; doi:10.1038/bjc.2017.101

Comment on ‘Renewed interest in the progesterone receptor in breast cancer’ FREE

Giovanni Simone, Sergio Diotaiuti, Maria Digennaro, Domenico Sambiasi, Simona De Summa, Stefania Tommasi, Rosanna Altieri, Annita Mangia, Caterina Dantona and Angelo Paradiso

Br J Cancer advance online publication, April 11, 2017; doi:10.1038/bjc.2017.90

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March 21 2017

Corrigendum

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer FREE

A Kenneth MacLeod, Lourdes Acosta-Jimenez, Philip J Coates, Michael McMahon, Frank A Carey, Tadashi Honda, John D Hayes, Colin J Henderson and C Roland Wolf

Br J Cancer advance online publication, March 21, 2017; doi:10.1038/bjc.2017.80

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