¹Center for Comprehensive and Advanced Medicine, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

Correspondence: Dr T Kubota, E-mail: tkubota@sc.itc.keio.ac.jp

Received 18 October 2007; Revised 10 January 2008; Accepted 4 March 2008; Published online 25 March 2008.

Abstract

S-1 is a potent antitumour drug in gastric cancer. After years of disagreement about the utility of chemotherapy for advanced gastric cancer, several studies have recently demonstrated the efficacy of S-1 in both the adjuvant and primary settings. In this Minireview, the value of S-1 in the treatment of gastric cancer is discussed.