Abstract
It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells.
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Greaves, M. Stem cell origins of leukaemia and curability. Br J Cancer 67, 413–423 (1993). https://doi.org/10.1038/bjc.1993.81
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DOI: https://doi.org/10.1038/bjc.1993.81
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