Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cardiac multiomics

Spatially resolved multiomics reveals the microanatomy of the human heart

Nature Cardiovascular Research volume 2, pages 798–800 (2023)Cite this article

Subjects

Spatially resolved multiomics is an emerging approach for profiling gene expression at the cellular level while maintaining the spatial organization of tissues. Its application in healthy human hearts provides insight into ion channels and regulatory signaling in the cardiac conduction system, cardiac cellular niches and drug–cell interactions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Cardiac niche characterization from spatially resolved multiomics and future applications for drug2cell.

References

  1. Williams, C. G., Lee, H. J., Asatsuma, T., Vento-Tormo, R. & Haque, A. Genome Med. 14, 68 (2022).

  2. Murthy, P. K. L. et al. Nature 604, 111–119 (2022).

    Article  Google Scholar 

  3. Foster, D. S. et al. Proc. Natl Acad. Sci. USA 118, e2110025118 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Hirz, T. et al. Nat. Commun. 14, 663 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Asp, M. et al. Cell 179, 1647–1660.e19 (2019).

    Article  CAS  PubMed  Google Scholar 

  6. Kuppe, C. et al. Nature 608, 766–777 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kanemaru, K. et al. Nature 619, 801–810 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mantri, S. et al. Curr Cardiol Rep. 23, 103 (2021).

    Article  PubMed  Google Scholar 

  9. Linscheid, N. et al. Nat. Commun 10, 2889 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Malysz, J. et al. Am. J. Physiol. 312, G228–G245 (2017).

    Google Scholar 

  11. Yue, Z. et al. Am. J. Physiol. 308, H157–H182 (2015).

    CAS  Google Scholar 

  12. Efremova, M., Vento-Tormo, M., Teichmann, S. A. & Vento-Tormo, R. Nat. Protoc. 15, 1484–1506 (2020).

  13. Xie, D. et al. Cell Res. 31, 951–964 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Pius‐Sadowska, E. & Machaliński, B. ESC Heart Fail. 8, 974–987 (2021).

  15. Coatsky, T. et al. J. Pharmacol. Toxicol. Methods 81, 15–20 (2016).

Download references

Acknowledgements

S.J. is supported by the Sarnoff Foundation. S.L.R. has a Career Award from the Burroughs Wellcome Foundation.

Author information

Authors and Affiliations

  1. Department of Medicine, Cardiovascular Division, Washington University in St Louis, School of Medicine, St Louis, MO, USA

    Samuel Jordan & Stacey L. Rentschler

  2. Department of Developmental Biology, Washington University in St Louis, School of Medicine, St Louis, MO, USA

    Stacey L. Rentschler

  3. Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO, USA

    Stacey L. Rentschler

Authors
  1. Samuel Jordan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stacey L. Rentschler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stacey L. Rentschler.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jordan, S., Rentschler, S.L. Spatially resolved multiomics reveals the microanatomy of the human heart. Nat Cardiovasc Res 2, 798–800 (2023). https://doi.org/10.1038/s44161-023-00327-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-023-00327-6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing