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Electrophysiology

Profiling the Ca2+ spark dynamics in live cardiomyocytes

Nature Cardiovascular Research volume 2, pages 225–226 (2023)Cite this article

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Calcium sparks are the elementary detectable units of calcium release through ryanodine receptors (RyRs). Hou et al. correlate Ca2+ sparks with RyR cluster configurations and provide insights into the dynamics of Ca2+ release in live cardiomyocytes at baseline and in pathological conditions.

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References

  1. Ringer, S. J. Physiol. 4, 29–42.3 (1883).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Fabiato, A. & Fabiato, F. Nature 281, 146–148 (1979).

    Article  CAS  PubMed  Google Scholar 

  3. Pessah, I. N., Waterhouse, A. L. & Casida, J. E. Biochem. Biophys. Res. Commun. 128, 449–456 (1985).

    Article  CAS  PubMed  Google Scholar 

  4. Stern, M. D. Biophys. J. 63, 497–517 (1992).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cheng, H., Lederer, W. J. & Cannell, M. B. Science 262, 740–744 (1993).

    Article  CAS  PubMed  Google Scholar 

  6. Franzini-Armstrong, C., Protasi, F. & Ramesh, V. Biophys. J. 77, 1528–1539 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hou, Y. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00199-2 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Gómez, A. M. et al. Science 276, 800–806 (1997).

    Article  PubMed  Google Scholar 

  9. Kerfant, B. G., Vassort, G. & Gómez, A. M. Circ. Res. 88, E59–E65 (2001).

    Article  CAS  PubMed  Google Scholar 

  10. Valdivia, H. H., Kaplan, J. H., Ellis-Davies, G. C. & Lederer, W. J. Science 267, 1997–2000 (1995).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Fu, Y. et al. Circulation 133, 388–397 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ruiz-Hurtado, G. et al. J. General Physiol. 146, 295–306 (2015).

    Article  CAS  Google Scholar 

  13. Yin, L. et al. Circ. Res. 129, e35–e52 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Song, L.-S. et al. Proc. Natl Acad. Sci. USA 103, 4305–4310 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was funded by the French Agency of Research (ANR-19-CE14-0031-01) and the National Institutes of Health (2R01HL055438-22). A.V.B. is a fellow of the Fondation Lefoulon Delalande.

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Authors and Affiliations

  1. Inserm, UMR-S 1180, Signaling and Cardiovascular Pathophysiology, Université Paris-Saclay, Orsay, France

    Laetitia Pereira, Almudena Val-Blasco, Jean-Pierre Benitah & Ana M. Gómez

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  1. Laetitia Pereira
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  2. Almudena Val-Blasco
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  3. Jean-Pierre Benitah
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  4. Ana M. Gómez
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Correspondence to Ana M. Gómez.

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Pereira, L., Val-Blasco, A., Benitah, JP. et al. Profiling the Ca2+ spark dynamics in live cardiomyocytes. Nat Cardiovasc Res 2, 225–226 (2023). https://doi.org/10.1038/s44161-022-00203-9

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