Palladium-catalysed enantioselective α-arylation of azlactones and 5H-oxazol-4-ones with aryl halides using Sadphos ligands enables the synthesis of α-aryl quaternary amino acids and glycolic acid derivatives.
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dos Santos, J.A., Amarante, G.W. Making α-aryl quaternary stereocentres. Nat. Synth 3, 293–295 (2024). https://doi.org/10.1038/s44160-023-00445-w
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DOI: https://doi.org/10.1038/s44160-023-00445-w