Catalytic templates produce oligomers of a defined length, moving beyond stoichiometric ratios of template to substrate. Bifunctional catalytic macrocycles with a defined cavity have a high affinity for the monomer but not the oligomer, enabling high-turnover oligomer synthesis.
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Ferguson, C.T.J., O’Reilly, R.K. Catalytic cavities control oligomer length. Nat. Synth 2, 311–312 (2023). https://doi.org/10.1038/s44160-023-00244-3
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DOI: https://doi.org/10.1038/s44160-023-00244-3
