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  • Clinical Outlook
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CLINICAL OUTLOOK

KRAS inhibitors, approved

Nature Cancer volume 2, pages 1254–1256 (2021)Cite this article

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An Author Correction to this article was published on 04 April 2022

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The rapid progression of KRAS(G12C) inhibitors from preclinical characterization to the clinic has radically changed the perception of the KRAS oncogene as an undruggable target. Here we discuss ongoing and future possibilities for developing therapies using these inhibitors in clinical settings.

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Fig. 1: Intrinsic and acquired mechanisms of resistance to targeted KRAS(G12C) inhibitors in NSCLC.

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References

  1. Kim, D., Xue, J. Y. & Lito, P. Cell 183, 850–859 (2020).

    Article  CAS  Google Scholar 

  2. Li, C. et al. Science 374, https://doi.org/10.1126/science.abf1730 (2021).

  3. Lou, K. et al. Sci. Signal. 12, eaaw9450 (2019).

    Article  CAS  Google Scholar 

  4. Manchado, E. et al. Nature 534, 647–651 (2016).

    Article  CAS  Google Scholar 

  5. Koga, T. et al. J. Thorac. Oncol. 16, 1321–1332 (2021).

    Article  CAS  Google Scholar 

  6. Xue, J. Y. et al. Nature 577, 421–425 (2020).

    Article  CAS  Google Scholar 

  7. Kruspig, B. et al. Sci. Transl. Med. 10, eaao2565 (2018).

    Article  Google Scholar 

  8. Hong, D. S. et al. N. Engl. J. Med. 383, 1207–1217 (2020).

    Article  CAS  Google Scholar 

  9. Skoulidis, F. et al. N. Engl. J. Med. 384, 2371–2381 (2021).

    Article  CAS  Google Scholar 

  10. US Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-first-targeted-therapy-lung-cancer-mutation-previously-considered-resistant-drug (2021).

  11. Awad, M. M. et al. N. Engl. J. Med 384, 2382–393 (2021).

    Article  CAS  Google Scholar 

  12. Tulpule, A. et al. Cell 184, 2649–2664.e2618 (2021).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

R.R. reports funding from the Spanish Association Against Cancer (AECC; grant PROYE18012ROSE), a European Union Horizon 2020 research and innovation program, Marie Sklodowska-Curie grant agreement ELBA N 765492 and the Talent-UAB grant to support recruitment and retention of research talent at the Autonomous University of Barcelona.

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Authors and Affiliations

  1. Catalan Institute of Oncology, Badalona, Spain

    Rafael Rosell

  2. Oncology Institute Dr Rosell, IOR, Barcelona, Spain

    Rafael Rosell & Andrés Aguilar

  3. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

    Rafael Rosell, Carlos Pedraz & Imane Chaib

Authors
  1. Rafael Rosell
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  2. Andrés Aguilar
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  3. Carlos Pedraz
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  4. Imane Chaib
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Correspondence to Rafael Rosell.

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Rosell, R., Aguilar, A., Pedraz, C. et al. KRAS inhibitors, approved. Nat Cancer 2, 1254–1256 (2021). https://doi.org/10.1038/s43018-021-00289-3

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