Here, we reveal functional heterogeneity among β cells and discover that readily releasable β cells (RRβs) are a subpopulation that disproportionally contributes to biphasic glucose-stimulated insulin secretion. We further show that the dysfunction of RRβs has a crucial role in the progression of diabetes.
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This is a summary of: Peng, X. et al. Readily releasable β cells with tight Ca2+–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion. Nat. Metab. https://doi.org/10.1038/s42255-023-00962-0 (2024).
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Functionally heterogeneous β cells regulate biphasic insulin secretion. Nat Metab 6, 207–208 (2024). https://doi.org/10.1038/s42255-023-00964-y
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DOI: https://doi.org/10.1038/s42255-023-00964-y
