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FOLATE METABOLISM

A new foe in folate metabolism

Nature Metabolism volume 3, pages 1436–1438 (2021)Cite this article

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A Publisher Correction to this article was published on 13 December 2021

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Two studies unmask the essentiality of methionine synthase activity in powering the folate cycle to replenish the tetrahydrofolate pool from 5-methyltetrahydrofolate; this generates nucleotides that support tumour growth. Dietary manipulation alters folate availability and holds implications for anti-cancer therapy response.

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Fig. 1: Methionine synthase replenishes the tetrahydrofolate pool to drive nucleotide synthesis in tumours under physiological folate condition.

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Acknowledgements

W.L.T. is supported by the National Medical Research Council, Singapore (OFIRG17may061, OFIRG19nov-0106, CTGIIT18may0012, NMRC/CIRG/1470/2017, NMRC/OFLCG/002-2018, NMRC/TCR15Jun006), National Research Foundation, Singapore (NRF-NRFF2015-04, NRF-CRP22-2019-0003, NRF-CRP23-2019-0004), Agency for Science, Technology and Research, Singapore, and the Singapore Ministry of Education under its Research Centers of Excellence initiative.

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Authors and Affiliations

  1. Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Zhengwei Wu & Wai Leong Tam

  2. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

    Zhengwei Wu & Wai Leong Tam

  3. NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore

    Wai Leong Tam

  4. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Wai Leong Tam

  5. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

    Wai Leong Tam

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  1. Zhengwei Wu
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Correspondence to Wai Leong Tam.

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Wu, Z., Tam, W.L. A new foe in folate metabolism. Nat Metab 3, 1436–1438 (2021). https://doi.org/10.1038/s42255-021-00474-9

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