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ASYMMETRIC CATALYSIS

Enantioconvergent hydrogenations

Nature Catalysis volume 1, pages 379–380 (2018)Cite this article

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The need for new single enantiomer drug substances helps drive the development of new asymmetric catalytic synthetic methods. A new enantioconvergent process enabled by an ionization racemization mechanism allows a hydrogenative route to chiral compounds with two stereocentres.

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Fig. 1: The evolution of synthesis of enantioenriched molecules.

References

  1. Hartwig, J. Nature 437, 487–488 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Knowles, W. S. Acc. Chem. Res. 16, 106–112 (1983).

    Article  CAS  Google Scholar 

  3. Pellissier, H. Adv. Synth. Catal. 353, 1613–1666 (2011).

    Article  CAS  Google Scholar 

  4. Bhat, V., Welin, E. R., Guo, X. & Stoltz, B. M. Chem. Rev. 117, 4528–4561 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rachwalski, M., Vermue, N. & Rutjes, F. P. J. T. Chem. Soc. Rev. 42, 9268–9282 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Pellissier, H. Tetrahedron 67, 3769–3802 (2011).

    Article  CAS  Google Scholar 

  7. Pellissier, H. Tetrahedron 64, 1563–1601 (2008).

    Article  CAS  Google Scholar 

  8. Pellissier, H. Tetrahedron 59, 8291–8327 (2003).

    Article  CAS  Google Scholar 

  9. Shimizu, H., Nagasaki, I., Matsumura, K., Sayo, N. & Saito, T. Acc. Chem. Res. 40, 1385–1393 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Liu, J., Krajangsri, S., Yang, J., Li., J.-Q. & Andersson, P. G. Nat. Catal. https://doi.org/10.1038/s41929-018-0070-0 (2018).

  11. Ebbers, E. J., Ariaans, G. J. A., Houbiers, J. P. M., Bruggink, A. & Zwanenburg, B. Tetrahedron 53, 9417–9476 (1997).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Jessica A. Griswold & Jeffrey S. Johnson

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  1. Jessica A. Griswold
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  2. Jeffrey S. Johnson
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Correspondence to Jeffrey S. Johnson.

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Griswold, J.A., Johnson, J.S. Enantioconvergent hydrogenations. Nat Catal 1, 379–380 (2018). https://doi.org/10.1038/s41929-018-0073-x

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