Retraction of: Scientific Reports https://doi.org/10.1038/s41598-021-96351-2, published online 15 October 2021
The Editors are retracting this Article.
This follows an investigation by the City of Hope Medical Centre that found discrepancies in the data. Specifically:
-
In Supplementary Fig. 1B, the fluorescence microscopy image of a culture of hiPSC line DF-19-9-7T was obtained from a derivative of hiPSC line 1157.2, specifically targeted using CRISPR to delete the gene ATRX.
-
In Supplementary Fig. 1E, the electron microscopy image of a megakaryocyte on day 6 of maturation was not obtained directly by differentiation of commercially available hiPSC line DF-19-9-7T as described, but instead from an immortalized megakaryocyte cell line (four days after doxycycline-withdrawal induction of differentiation), previously derived from a hiPSC line.
-
In Supplementary Fig. 1C, the karyotype image from a cell from the hiPSC line DF-19-9-7T was obtained from hiPSC line 1156.
Additional, the investigation found that these data and the electron microscopy image presented in Fig. 2D were not owned by the Authors. The Editors no longer have confidence in the reliability of the data reported.
Khairul Ansari, Mike Y. Chen and Rahul Jandial agree with the retraction and its wording. Arunoday Bhan did not respond to the correspondence from the Editors about the retraction.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Bhan, A., Ansari, K., Chen, M.Y. et al. Retraction Note: Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain. Sci Rep 14, 5972 (2024). https://doi.org/10.1038/s41598-024-56291-z
Published:
DOI: https://doi.org/10.1038/s41598-024-56291-z
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
