The identification of sodium and potassium currents as underlying action potential propagation, more than 70 years ago, opened a new avenue of research into the role of ion channels. In this Comment, we present our personal perspectives of the field, from the identification of Shaker as a potential potassium channel to the mechanistic insights available to us today.
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Acknowledgements
We appreciate the collegiality of the ion channel field, and we thank former and current lab members for their scientific contributions to this field. L.Y.J. and Y.N.J. are investigators of the Howard Hughes Medical Institute and supported by NIH grants R35NS122110 (to L.Y.J.) and R35NS097227 (to Y.N.J.).
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Jan, L.Y., Jan, Y.N. A personal perspective of the voltage-gated potassium channel studies. Nat Struct Mol Biol 31, 580–581 (2024). https://doi.org/10.1038/s41594-024-01267-w
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DOI: https://doi.org/10.1038/s41594-024-01267-w
