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Structure-guided drug discovery: back to the future

Nature Structural & Molecular Biology volume 31, pages 395–396 (2024)Cite this article

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Over the past 30 years, the field of structural biology and its associated biological insights have seen amazing progress. In this Comment, I recount several milestones in the field and how we can apply lessons from the past toward an exciting future, especially as it relates to drug discovery.

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Acknowledgements

C.H.A. is funded by the Canadian Institutes for Health Research (FDN154328 and OGB190363), Canada foundation for Innovation, National Institutes of Health (U19 AI171292), Huntington Society of Canada, Princess Margaret Cancer Centre, The Princess Margaret Cancer Foundation, and Ontario Ministry of Health. The Structural Genomics Consortium is a registered charity (no. 1097737) that receives funds from Bayer AG, Boehringer Ingelheim, Bristol Myers Squibb, Genentech, Genome Canada through Ontario Genomics Institute (OGI-196), EU/EFPIA/OICR/McGill/KTH/Diamond Innovative Medicines Initiative 2 Joint Undertaking (EUbOPEN grant 875510), Janssen, Merck (known as EMD in Canada and the United States), Pfizer and Takeda.

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Authors and Affiliations

  1. Princess Margaret Cancer Centre, Toronto, Ontario, Canada

    Cheryl H. Arrowsmith

  2. Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada

    Cheryl H. Arrowsmith

  3. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    Cheryl H. Arrowsmith

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  1. Cheryl H. Arrowsmith
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Correspondence to Cheryl H. Arrowsmith.

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Arrowsmith, C.H. Structure-guided drug discovery: back to the future. Nat Struct Mol Biol 31, 395–396 (2024). https://doi.org/10.1038/s41594-024-01244-3

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