The activity of genes is controlled by regulatory DNA sequences, which interact and communicate with their target genes over long genomic distances. New analyses show that the Mediator complex contributes to the formation of these long-range interactions in the genome.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Krijger, P. H. L. & de Laat, W. Regulation of disease-associated gene expression in the 3D genome. Nat. Rev. Mol. Cell Biol. 17, 771–782 (2016). This review article is about long-range interactions in the genome and their relevance in development and disease.
Richter, W. F., Nayak, S., Iwasa, J. & Taatjes, D. The Mediator complex as a master regulator of transcription by RNA polymerase II. Nat. Rev. Mol. Cell Biol. 23, 732–749 (2022). This review article is about the Mediator complex.
Jaeger, M. G. et al. Selective Mediator dependence of cell-type-specifying transcription. Nat. Genet. 52, 719–727 (2020). This paper presents an approach for rapid depletion of Mediator and characterizes the role of Mediator in transcription regulation.
Aljahani, A. et al. Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF. Nat. Commun. 13, 2139 (2022).
Hua, P. et al. Defining genome architecture at base-pair resolution. Nature 595, 125–129 (2021). These papers (refs. 4,5) present high-resolution approaches for the analysis of regulatory interactions in the genome.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Ramasamy, S. et al. The Mediator complex regulates enhancer-promoter interactions. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01027-2 (2023).
Rights and permissions
About this article
Cite this article
The Mediator complex regulates long-range communication in the genome. Nat Struct Mol Biol 30, 876–877 (2023). https://doi.org/10.1038/s41594-023-01028-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-023-01028-1
