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Intraflagellar transport

Architecture of intraflagellar transport complexes

Nature Structural & Molecular Biology volume 30, pages 570–573 (2023)Cite this article

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Cilia — or flagella, as they are interchangeably termed — are appendage-like organelles extending from eukaryotic cells. Several recent structural studies on intraflagellar transport (IFT) trains shed light on these fascinating complexes, including their assembly mechanism, stability, cargo recruitment and evolution.

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Fig. 1: Structure of cilium and IFT.
Fig. 2: Structures and phylogeny of IFT-A and IFT-B components.
Fig. 3: In situ structure of IFT train.

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Acknowledgements

The author thanks G. Pigino and A. Roberts for providing density map and coordinates used in the figures. The study of the author is funded by grant from Swiss National Science Foundation (310030_192644).

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  1. Department of Biology and Chemistry, Paul Scherrer Institute Villigen, Villigen, Switzerland

    Takashi Ishikawa

  2. Department of Biology, ETH Zurich, Zurich, Switzerland

    Takashi Ishikawa

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Correspondence to Takashi Ishikawa.

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Ishikawa, T. Architecture of intraflagellar transport complexes. Nat Struct Mol Biol 30, 570–573 (2023). https://doi.org/10.1038/s41594-023-00986-w

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