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NONCODING RNA

Turning the table on miRNAs

Nature Structural & Molecular Biologyvolume 25pages195197 (2018) | Download Citation

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Transcripts with highly complementary sequences can target microRNAs (miRNAs) for degradation, but the physiological relevance of target-directed miRNA degradation (TDMD) has remained unclear. Bitetti et al. now identify a conserved vertebrate RNA that induces TDMD in the cerebellum of zebrafish and mouse to promote wild-type animal behaviors.

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Affiliations

  1. Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Buenos Aires, Argentina

    • Manuel de la Mata
  2. CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Ciudad Universitaria, Buenos Aires, Argentina

    • Manuel de la Mata
  3. Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland

    • Helge Großhans
  4. University of Basel, Basel, Switzerland

    • Helge Großhans

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Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Manuel de la Mata or Helge Großhans.

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DOI

https://doi.org/10.1038/s41594-018-0040-x